M2816

メタスチン(45-54)アミド, ヒト

≥95%

• 別名: KiSS-1, キスペプチン-10, 遺伝子産物(112-121)アミド, ヒト
• 実験式（ヒル表記法）: C₆₃H₈₃N₁₇O₁₄
• 分子量: 1302.44
• MDL番号: MFCD03452696
• UNSPSCコード: 12352200
• PubChem Substance ID: 329817951
• NACRES: NA.32

特性

• 品質水準: 200
• アッセイ: ≥95%
• UniProtアクセッション番号: Q15726
• 保管温度: −20°C
• SMILES記法: CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc4ccc(O)cc4)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc5ccccc5)C(N)=O
• InChI: 1S/C63H83N17O14/c1-34(2)24-45(58(90)74-43(18-11-23-70-63(68)69)57(89)75-44(54(67)86)26-35-12-5-3-6-13-35)73-53(85)32-72-56(88)46(27-36-14-7-4-8-15-36)77-62(94)50(33-81)80-61(93)49(30-52(66)84)79-59(91)47(28-38-31-71-42-17-10-9-16-40(38)42)78-60(92)48(29-51(65)83)76-55(87)41(64)25-37-19-21-39(82)22-20-37/h3-10,12-17,19-22,31,34,41,43-50,71,81-82H,11,18,23-30,32-33,64H2,1-2H3,(H2,65,83)(H2,66,84)(H2,67,86)(H,72,88)(H,73,85)(H,74,90)(H,75,89)(H,76,87)(H,77,94)(H,78,92)(H,79,91)(H,80,93)(H4,68,69,70)/t41-,43-,44-,45-,46-,47-,48-,49-,50-/m0/s1
• InChI Key: RITKWYDZSSQNJI-INXYWQKQSA-N
• 遺伝子情報: human ... KISS1(3814)

詳細

Amino Acid Sequence

Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2

詳細

Metastin is also known as kisspeptin 1 (KISS1). It is encoded by KISS1 gene, that is mapped to human chromosome 1q32. Metastin is a tumor suppressor protein, made up of 145 amino acids. The protein fragments contain RFamide motif at the C- terminal end. The encoded protein is expressed in the human hypothalamus, gonads, placenta, liver and pancreas. This novel peptide is mainly isolated from the human placenta.

アプリケーション

Metastin (45-54) amide has been used in progesterone release experiments from MA-10 cells. It has also been used to induce gonadal differentiation in clownfish.

生物化学的／生理学的作用

メタスチンは、OT7T175(別名AXOR12)やGPR54のようなGタンパク質共役型オ-ファンレセプタ-の内在性リガンドです。胎盤由来の新規ホルモンです。アミド型のメタスチンは、メタスチンの遊離酸型に比べて3~10倍の作用が認められています。

Metastin functions as a tumor suppressor via inhibiting secondary tumor growth. Activation of KISS1R (KISS1 receptor), upon binding KISS1, enhances intracellular calcium and activates MAPKs, which restricts cell motility and proliferation. Metastin acts as a potential therapeutic target for various cancers including melanoma, thyroid cancer and bladder cancer, squamous cell carcinoma of the esophagus gastric cancer, hepatocellular carcinoma and breast cancer. Metastin has a crucial role in reproduction. It regulates hypothalamic-pituitary-gonadal axis role via controlling gonadotropin-releasing hormone (GnRH) secretion and determines the onset of puberty. Mutation of the gene leads to central precocious puberty (CPP) in male and dysfunction of metastin signaling causes isolated hypogonadotropic hypogonadism (IHH) in humans and mice. Metastin has the ability to enhance the plasma levels of gonadotropins (follicle-stimulating hormone and luteinizing hormone) and stimulate ovulation in prepubertal female rats.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)