H8041

IL-23 human

HumanKine^®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture

• 別名: Human IL-23, IL-23 Cytokine, Interleukin 23
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• 製品名: インターロイキン-23 ヒト, IL-23, recombinant, expressed in HEK 293 cells, HumanKine^®, suitable for cell culture
• 由来生物: human
• 品質水準: 100
• リコンビナント: expressed in HEK 293 cells
• アッセイ: ≥95% (SDS-PAGE)
• フォーム: lyophilized powder
• 有効性: ≤2 ng/mL EC₅₀
• 品質: endotoxin tested
• 分子量: dimer 55 kDa (glycosylated)
• 包装: pkg of 5X10 μg; pkg of 10 μg; pkg of 5 μg
• テクニック: cell culture | mammalian: suitable
• 不純物: ≤1EU/mg
• UniProtアクセッション番号: Q9NPF7
• 保管温度: −20°C
• 遺伝子情報: human ... IL23A(51561)

詳細

詳細

HumanKine interleukin-23 (IL-23) is expressed as a heterodimeric 55 kDa cytokine composed of two glycosylated and disulfide linked subunits (p40 cystine linked to p19). Production in human HEK 293 cells offers authentic glycosylation. Cytokines produced in Sf9 or Sf21 cells have post-translational modifications, which are not human-like.

Interleukin-23 (IL-23) is a pro-inflammatory cytokine. It is mostly synthesized by activated dendritic cells and macrophages. It is a 20.7kDa protein with 189 amino acids. IL-23 is mostly expressed on activated/memory T cells and natural killer (NK) cells. This gene is located on human chromosome 12q13.3.

生物化学的／生理学的作用

Interleukin-23 (IL-23) plays a major role in cutaneous immune-mediated inflammatory diseases like psoriasis, allergic contact dermatitis and atopic dermatitis. It is involved in cellular immunity, driving the expansion, stabilization and survival of Th17 cells.

アナリシスノート

特異的活性は、10 ng/mL PMAによって活性化されるマウス脾細胞からのIL-17の用量依存的な分泌によって確認されました。

法的情報

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1