D7810

抗Daxx抗体 ウサギ宿主抗体

IgG fraction of antiserum, buffered aqueous solution

• 別名: Anti-BING2, Anti-DAP6, Anti-EAP1, Anti-SMIM40
• MDL番号: MFCD01865517
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: IgG fraction of antiserum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen 120 kDa
• 化学種の反応性: mouse, human, monkey
• テクニック: microarray: suitable; western blot: 1:4,000 using human acute lymphoma Jurkat whole cell extract
• UniProtアクセッション番号: Q9UER7
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... DAXX(1616) ; mouse ... Daxx(13163)

詳細

詳細

Death domain associated protein (Daxx), also known as ETS associated protein 1 (EAP1), is an adaptor protein that binds to the death domain of Fas. Daxx is a 120 kDa protein with a nuclear localization signal sequence. It is highly acidic due to extended glutamic acid-rich domains. Daxx mRNA is extensively expressed in fetal and adult human and mouse tissues. Daxx has also been found in the nucleus where it localizes with the promyelocytic leukemia protein (PML), a gene of acute promyelocytic leukemia (APL).

特異性

Anti-Daxx specifically recognizes human Daxx (120 kDa).

免疫原

Synthetic peptide corresponding to the C-terminus of human Daxx. This sequence is identical in mouse and monkey.

アプリケーション

Anti-Daxx antibody is suitable for:

• western blot (1:4,000 using human acute lymphoma Jurkat whole cell extract)
• microarray
• the detection and localization of Daxx by immunoblotting

Anti-Daxx antibody produced in rabbit has been used to visualize hDaxx.

生物化学的／生理学的作用

The death domain-associated protein (Daxx) is a protein that interacts with FAS and subsequently regulates cellular apoptosis. Daxx also interacts with H3.3 histone and α-thalassemia X-linked mental retardation protein (ATRX) to regulate chromatin deposition at telomeres. In addition, it also acts as a pro-apoptotic molecule that can specifically enhance Fas-induced apoptosis by activating the Jun N-terminal kinase (JNK) signaling pathway, through its interaction with the apoptosis signal-regulating kinase 1 (ASK1).

物理的形状

0.01 M PBS溶液(pH 7.4, 15 mMアジ化ナトリウム含有)。

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)