G8134

ガラミントリエチオジド

≥98% (TLC), powder, muscarinic receptor antagonist

• 実験式（ヒル表記法）: C₃₀H₆₀I₃N₃O₃
• CAS番号: 65-29-2
• 分子量: 891.53
• EC Number: 200-605-1
• MDL番号: MFCD00011832
• UNSPSCコード: 12352116
• PubChem Substance ID: 24277837
• NACRES: NA.77

特性

• 品質水準: 200
• アッセイ: ≥98% (TLC)
• フォーム: powder
• mp: 235 °C (dec.) (lit.)
• 溶解性: H₂O: 100 mg/mL; ethanol: soluble
• 保管温度: 2-8°C
• SMILES記法: [I-].[I-].[I-].CC[N+](CC)(CC)CCOc1cccc(OCC[N+](CC)(CC)CC)c1OCC[N+](CC)(CC)CC
• InChI: 1S/C30H60N3O3.3HI/c1-10-31(11-2,12-3)22-25-34-28-20-19-21-29(35-26-23-32(13-4,14-5)15-6)30(28)36-27-24-33(16-7,17-8)18-9;;;/h19-21H,10-18,22-27H2,1-9H3;3*1H/q+3;;;/p-3
• InChI Key: REEUVFCVXKWOFE-UHFFFAOYSA-K
• 遺伝子情報: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133) , CHRNA1(1134) , CHRNB1(1140) , CHRND(1144) , CHRNE(1145) , CHRNG(1146)

詳細

アプリケーション

Gallamine triethiodide has been used:

• as a relaxant for measuring spinal trigeminal nucleus recordings from single neurons.
• as an antagonist in neuroblastoma cells as M2 receptor
• to reduce eye movement during retinal surgery in rat

生物化学的／生理学的作用

筋弛緩剤であり、ムスカリン受容体のアロステリックアンタゴニスト (強度の強い順に、M₂ > M₁ = M₄ > M₃ = M₅) です。末梢におけるアセチルコリンエステラ-ゼのアニオン性結合部位のリガンドです。

Gallamine triethiodide has anti-muscarinic effect. It is a competitive antagonist for the muscarinic receptor. Gallamine is regarded as neuromuscular blocking agent.

特徴および利点

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

注意

Hygroscopic

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves