F7301

繊維芽細胞増殖因子-18 ヒト

>95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder

• 別名: FGF-18
• EC Number: 201-064-4
• MDL番号: MFCD01867042
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• 由来生物: human
• 品質水準: 200
• リコンビナント: expressed in E. coli
• アッセイ: >95% (SDS-PAGE and HPLC)
• 形状: lyophilized powder
• 有効性: ≤0.5 ng/mL
• 分子量: predicted mol wt 21.2 kDa
• 包装: pkg of 25 μg
• 保管条件: avoid repeated freeze/thaw cycles
• 不純物: endotoxin, tested
• UniProtアクセッション番号: O76093
• 保管温度: −20°C
• 遺伝子情報: human ... FGF18(8817)

詳細

詳細

FGF18 (fibroblast growth factor 18) is a member of the FGF family, and is a part of the FGF8 subfamily, which also includes FGF8 and FGF17. It is a paracrine-acting protein, and does not undergo alternative splicing. It is produced as a precursor of 207 amino acids, from which the signal peptide of 27 hydrophobic amino acids is cleaved of. This gene is localized to human chromosome 5q35.1, which produces a protein of 21.2kDa.

生物化学的／生理学的作用

FGF-18はヘパリン結合性の増殖因子であり、FGFレセプタ-を発現する細胞の増殖や活性化を刺激します。

FGF18 (fibroblast growth factor 18) functions in both developing and adult organisms, and plays a predominant role in skeletal development. It is a putative early marker for prostate and ovarian cancer, and has potential as a target in the same. It mediates gene profiling, and has anticatabolic effects mediated through Timp1 (tissue inhibitor of metalloproteinases). Thus, it has confers protection on adult articular cartilage. In mice embryos, inactivation of this gene results in death due to aberrations in alveologenesis and skeleton development.

物理的形状

凍結乾燥品(0.2 μmフィルターで濾過滅菌済み、10 mM Tris溶液、pH 8.0、20 mM NaCl)。

アナリシスノート

生物活性は、FGFレセプタ-を発現するBaF3細胞のチミジン取り込みに対する用量依存的な刺激作用により測定しています。

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable