F6926

線維芽細胞増殖因子-8b マウス由来

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

• 別名: FGF-8b
• MDL番号: MFCD01323276
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• 由来生物: mouse
• 品質水準: 100
• リコンビナント: expressed in E. coli
• アッセイ: >97% (SDS-PAGE)
• 形状: lyophilized powder
• 有効性: 15-60 ng/mL
• 分子量: calculated mol wt 23.6 kDa; predicted mol wt 22 kDa
• 包装: pkg of 25 μg
• 保管条件: avoid repeated freeze/thaw cycles
• 不純物: endotoxin, tested
• UniProtアクセッション番号: P37237
• 保管温度: −20°C
• 遺伝子情報: mouse ... Fgf8(14179)

詳細

詳細

Fibroblast growth factor 8 (FGF8) is a member of the FGF family, and was initially cloned from androgen-dependent mouse mammary carcinoma cell line. Alternative splicing of this gene produces four different isoforms mainly, FGF8a, FGF8b, FGF8e and FGF8f.

アプリケーション

Fibroblast Growth Factor-8b from mouse has been used-

• for subgerminal cavity injection in fertilized quail, chicken, turtle and emu eggs
• in the induction of neural differentiation in stem cells from Human Exfoliated Deciduous teeth (SHED) and
• in experiments conducted on fertilized hens′ eggs, where FGF8 induced SOX3 gene.

生物化学的／生理学的作用

FGF-8bは、顔、四肢や中枢神経系の成長やパターン形成など原腸形成後の胚の外胚葉分化に関与しています。FGF-8bはFGFR-2、FGFR-3、FGFR-4のC末端スプライス型を活性化します。

Fibroblast growth factor 8b (FGF8b) isoform of FGF8 has the most potent angiogenic and tumorigenic properties. In prostate cancer, it is responsible for angiogenesis, tumorigenesis and invasion. Exogenous expression of this gene in prostate epithelium leads to prostatic intraepithelial neoplasia (PIN). It also interacts with pattern recognition receptor long pentraxin-3 (PTX3), which is involved in local inflammation.

物理的形状

Lyophilized from a 0.2μm filtered solution in 20mM MOPS, 0.1M sodium sulfate, 0.02% Brij-35, pH 7 containing 50ug of BSA per 1μg as a carrier protein

アナリシスノート

生物活性は、NR6R-3T3線維芽細胞の増殖刺激能で測定されています。

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319
• 注意書き: P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)