D4505

5,5-ジフェニルヒダントイン ナトリウム塩

≥99%

• 別名: 5,5-ジフェニル-2,4-イミダゾリジンジオン, フェニトイン
• 化学式: C₁₅H₁₁N₂O₂Na
• CAS番号: 630-93-3
• 分子量: 274.25
• EC Number: 211-148-2
• MDL番号: MFCD00069674
• UNSPSCコード: 12352200
• PubChem Substance ID: 24277707
• NACRES: NA.77

特性

• 品質水準: 200
• アッセイ: ≥99%
• 形状: powder
• 溶解性: aqueous base: soluble
• SMILES記法: [Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
• InChI: 1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
• InChI Key: FJPYVLNWWICYDW-UHFFFAOYSA-M
• 遺伝子情報: human ... CNR1(1268) , CNR2(1269) , CYP2C9(1559) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; rat ... Faah(29347) , Scn1a(81574) , Scnn1g(24768) , Slc6a1(79212)

詳細

詳細

5,5-Diphenylhydantoin sodium salt is a derivative of phenytoin. 5,5-Diphenylhydantoin is used for treating epilepsy and has antiepileptic activity. It functions by blocking the sodium channels and modulates excitation of neurons. However, the side effects include hypertrichosis and overgrowth of gum tissue around the teeth. It promotes proliferation of the neural stem cells by modulating growth factors. Diphenylhydantoin is toxic and induces apoptosis in cultured cerebellar granule neurons.

アプリケーション

5,5-Diphenylhydantoin sodium salt has been used:

• in the cream preparation for treating burn wounds
• in seizure behavior testing as an anticonvulsant in Drosophila
• in in vivo embryo toxicity test in mouse embryonic stem cells

生物化学的／生理学的作用

大発作の発生率を低減します。興奮性膜を安定化すると考えられており、これはおそらく、Na⁺, K⁺, Ca²⁺チャネルに対する作用を経由しています。

特徴および利点

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H317,H361
• 注意書き: P201 - P202 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• 危険有害性の分類: Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges