C9521

Z-Phe-Arg 7-amido-4-methylcoumarin hydrochloride

kallikrein substrate, ≥95% (HPLC), powder

• 別名: Z-Phe-Arg-AMC
• 実験式（ヒル表記法）: C₃₃H₃₆N₆O₆ · HCl
• CAS番号: 70382-26-2
• 分子量: 649.14
• MDL番号: MFCD00077030
• UNSPSCコード: 12352204
• PubChem Substance ID: 24893165
• NACRES: NA.32

特性

• product name: Z-Phe-Arg 7-amido-4-methylcoumarin hydrochloride, kallikrein substrate
• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: powder
• 濃度: ≥95%
• 溶解性: methanol: 20 mg/mL, clear, colorless
• 保管温度: −20°C
• SMILES記法: O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(NC2=CC=C(C(C)=CC(O3)=O)C3=C2)=O)=O)OCC4=CC=CC=C4.[Cl]
• InChI: 1S/C33H36N6O6/c1-21-17-29(40)45-28-19-24(14-15-25(21)28)37-30(41)26(13-8-16-36-32(34)35)38-31(42)27(18-22-9-4-2-5-10-22)39-33(43)44-20-23-11-6-3-7-12-23/h2-7,9-12,14-15,17,19,26-27H,8,13,16,18,20H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,34,35,36)
• InChI Key: ZZGDDBWFXDMARY-UHFFFAOYSA-N

詳細

詳細

Z-Phe-Arg 7-amido-4-methylcoumarin (Z-FR-AMC) is a peptidomimetic substrate for papainand other enzymes such as cathepsin K. It is also a fluorogenic synthetic peptide for the enzymes cathepsins L and B.

アプリケーション

Z-Phe-Arg 7-amido-4-methylcoumarin hydrochloride has been used:

• as a fluorogenic substrate in actinidin inhibition assay
• as a kallikrein substrate
• as a trypsin substrate for fluorometric assay
• as a cathepsin-L substrate

生物化学的／生理学的作用

Z-Phe-Arg 7-amido-4-methylcoumarin (Z-FR-AMC) proteolytic lysis by proteases leads to the liberation of AMC resulting in increased fluorescence in the enzymatic reaction.

基質

血漿カリクレインの蛍光基質です。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)