219555

Cathepsin K Substrate II, Fluorogenic

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/Km = 0.426 µM⁻¹ S⁻¹), but not by Cathepsins B/L/S/F/H/V.

• 別名: Cathepsin K Substrate II, Fluorogenic
• 実験式（ヒル表記法）: C₄₀H₅₀N₁₄O₁₂
• 分子量: 918.91
• UNSPSCコード: 51111800
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated; protect from light
• 色: bright yellow
• 溶解性: DMSO: 5 mg/mL
• 蛍光検出: λ_ex 320 nm; λ_em 420 nm
• 輸送温度: wet ice
• 保管温度: −20°C

詳細

詳細

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/K_m = 0.426 µM^-1 S^-1), but not by Cathepsins B/L/S/F/H/V. Studies using WT and CatK^-/- mice reveal that the substrate is not cleaved by other proteolytic enzymes present in fibroblast lysates. Emission Max: 420 NM, Excitation Max: 320 nM.

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (k_cat/Km = 0.426 µM⁻¹ S⁻¹), but not by Cathepsins B/L/S/F/H/V.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

シーケンス

Abz-His-Pro-Gly~Gly-Pro-Gln-EDDnp

物理的形状

Supplied as a trifluoroacetate salt.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Lecaille, F., et al. 2003. Biochem. J.375, 307.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable