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品質水準
アッセイ
≥97.0% (HPLC)
形状
powder or crystals
pKa
9.70
mp
170 °C
抗生物質活性スペクトル
Gram-negative bacteria
Gram-positive bacteria
作用機序
cell wall synthesis | interferes
保管温度
room temp
InChI
1S/C14H13N5O5S2/c1-2-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24)6-4-26-14(15)16-6/h2,4,8,12,24H,1,3H2,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/s1
InChI Key
RTXOFQZKPXMALH-GHXIOONMSA-N
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詳細
Chemical structure: ß-lactam
アプリケーション
Cefdinir was used to study bacterial infections caused by Staphylococcus aureus and Neisseria gonorrhoeae and the horizontal transfer of the ftsI gene in H. influenzae.
次世代のセファロスポリン系抗生物質グラム陽性菌およびグラム陰性菌に対し、バランスのとれた優れた抗菌作用を示します。
生物化学的／生理学的作用
Cefdinir is an advanced generation amino-2-thiazolyl cephalosporin effective against Gram-positive and Gram-negative bacteria. It acts by disrupting the synthesis of the peptidoglycan layer of bacterial cell walls. It is also known to inhibit human neutrophil myeloperoxidases.
その他情報
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
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Janet R Casey et al.
Drugs, 72(15), 1991-1997 (2012-10-09)
10 days of amoxicillin/clavulanic acid high dose and 5 days of cefdinir have been the preferred first- or second-line antibiotics for treatment of children with acute otitis media (AOM) since 2004, as recommended by the American Academy of Pediatrics in
Indi Trehan et al.
The New England journal of medicine, 368(5), 425-435 (2013-02-01)
Severe acute malnutrition contributes to 1 million deaths among children annually. Adding routine antibiotic agents to nutritional therapy may increase recovery rates and decrease mortality among children with severe acute malnutrition treated in the community. In this randomized, double-blind, placebo-controlled
M T Labro et al.
Journal of immunology (Baltimore, Md. : 1950), 152(5), 2447-2455 (1994-03-01)
Cefdinir, a new oral 2-amino-5-thiazolyl cephalosporin, inhibited the luminol-amplified chemiluminescence (LACL) response of human neutrophils stimulated by PMA but not opsonized zymosan, in a concentration-dependent but not time-dependent manner. The LACL response to opsonized zymosan in cytochalasin B-treated neutrophils was
Helio S Sader et al.
Expert review of anti-infective therapy, 5(1), 29-43 (2007-02-03)
Cefdinir is an oral third-generation cephalosporin (also known as an advanced-spectrum or generation cephem) with good in vitro activity against the pathogens responsible for community-acquired respiratory tract infections and uncomplicated skin and skin structure infections. The drug distributes very well
D R Guay
The Pediatric infectious disease journal, 19(12 Suppl), S141-S146 (2001-01-06)
Oral second and third generation cephalosporins are undergoing continuing research and development in the arena of pediatric infectious disease in an attempt to fill voids created by existing agents in the quest for the "ideal" antimicrobial. This paper reviews the
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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