C6607

カスパーゼ10 ヒト

>90% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, 8,000 units/mg protein (Bradford)

• 別名: Flice2, Mch4
• MDL番号: MFCD03456342
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• リコンビナント: expressed in E. coli
• 品質水準: 200
• アッセイ: >90% (SDS-PAGE)
• 形状: lyophilized powder
• 比活性: 8,000 units/mg protein (Bradford)
• 分子量: ~30 kDa
• 溶解性: PBS: soluble
• UniProtアクセッション番号: Q92851
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... CASP10(843)

詳細

生物化学的／生理学的作用

Caspase 10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase 10 cleaves and activates caspases 3, 4, 6, 7, 8 and 9 which causes the proteolytic cleavage of many key proteins such as PARP. Based on gene expression studies, caspase 10 may be crucial in embryonic development. In view of its structural homology to caspase 8, the initiator caspase in death receptor-mediated apoptosis, caspase 10 may function in a similar and redundant manner.

単位の定義

1ユニットは、pH 7.2、37°Cで1時間あたりカスパーゼ基質であるIETD-pNA 1 nmolをIETDおよびp-ニトロアニリンに加水分解する量です。

物理的形状

Lyophilized powder containing 0.052% ammonium sulfate, 0.158% Tris−HCl, and 0.76% sodium chloride.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable