C5737

Monoclonal Anti-Caspase 3 antibody produced in mouse

clone 84803.111, purified immunoglobulin, lyophilized powder

• 別名: 抗CPP32抗体, 抗Yama抗体, 抗アポパイン抗体
• MDL番号: MFCD01321906
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 84803.111, monoclonal
• フォーム: lyophilized powder
• 化学種の反応性: human
• テクニック: western blot: 1.0 μg/mL using human Jurkat cells
• アイソタイプ: IgG2b
• UniProtアクセッション番号: P42574
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CASP3(836)

詳細

詳細

CASP3 (caspase 3) is a cysteine protease belonging to the caspase protein family, and is related to interleukin-1β-converting enzyme (ICE). It is the human homologue of Caenorhabditis elegans Ced-3 protein. This protein forms a key element of apoptosis.

特異性

リコンビナントヒトカスパ-ゼ3前駆体およびアポト-シスで生じる18 kDa型を検出します。

免疫原

ヒトカスパ-ゼ3のリコンビナント18 kDaサブユニット(アミノ酸29-175)。

生物化学的／生理学的作用

CASP3 (caspase 3) is an essential protein of apoptosis, which includes multiple death-inducing signals, and caspase 3 functions at the last steps of programmed cell death. This protein is shown to be expressed in esophageal squamous cell carcinoma (ESCC), and its down-regulation is related to increased malignancy and reduced overall survival. Its expression in metastatic lymph nodes (LN) might serve as a marker for poor survival prognosis in patients with resected ESCC and metastasis to LN. Studies in multiple cancers such as, gastric, colorectal, ovarian and cervical cancers show that aberrant expression of this gene is linked with cancer progression and aggressive behavior. It might have potential as a marker to determine the prognosis of the above cancers.

物理的形状

凍結乾燥品(0.01 M PBS溶液, 5%トレハロ-ス含有, 0.2 μmフィルタ-滅菌済み)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable