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Merck

SAB4502234

Sigma-Aldrich

Anti-Cytochrome c antibody produced in rabbit

affinity isolated antibody

別名:

CYC, CYCS, Cytochrome c

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About This Item

UNSPSCコード:
12352203
NACRES:
NA.41

由来生物

rabbit

品質水準

結合体

unconjugated

抗体製品の状態

affinity isolated antibody

抗体製品タイプ

primary antibodies

クローン

polyclonal

フォーム

buffered aqueous solution

分子量

antigen 11 kDa

化学種の反応性

human, rat, mouse

濃度

~1 mg/mL

テクニック

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBIアクセッション番号

UniProtアクセッション番号

輸送温度

wet ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... CYCS(54205)

詳細

Anti-Cytochrome c antibody detects endogenous levels of total Cytochrome c protein.
The cytochrome c gene is mapped to human chromosome 7p15.3. The encoded protein consists of two thioether present between heme and two cysteine residues included in a CXXCH motif (highly conserved). It is localized to mitochondrial intermembrane space.

免疫原

The antiserum was produced against synthesized peptide derived from human Cytochrome c.

Immunogen Range: 10-59

アプリケーション

Anti-Cytochrome c, N-terminal antibody produced in rabbit has been used in western blot analysis.

生物化学的/生理学的作用

Cytochrome c is a water-soluble intermediary of electron transport chain. It acts as an ROS (reactive oxygen species) scavenger, and involved in redox-mediated protein import and apoptosis. Cytochrome c has peroxidase activity, contributing towards intrinsic pathway of apoptosis.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

ウサギIgGのPBS溶液(Mg2+およびCa2+を含まず)、pH 7.4、150 mM NaCl、0.02% アジ化ナトリウム、50% グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

WGK

nwg

引火点(°F)

Not applicable

引火点(℃)

Not applicable


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Erez Eitan et al.
Cerebellum (London, England), 15(4), 509-517 (2015-09-17)
Telomerase reverse transcriptase (TERT) is the catalytic subunit of telomerase, an enzyme that elongates telomeres at the ends of chromosomes during DNA replication. Recently, it was shown that TERT has additional roles in cell survival, mitochondrial function, DNA repair, and
Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis.
Jiang X
Proceedings of the National Academy of Sciences of the USA, 111(41), 14782-14787 (2014)
Apobec2 deficiency causes mitochondrial defects and mitophagy in skeletal muscle.
Sato Y
Faseb Journal (2017)
Evaluation of the adaptogenic potential exerted by ginsenosides Rb1 and Rg1 against oxidative stress-mediated neurotoxicity in an in vitro neuronal model.
Fernandez-Moriano C
PLoS ONE, 12(8), 1-22 (2017)
Effect of a K72A Mutation on the Structure, Stability, Dynamics, and Peroxidase Activity of Human Cytochrome c.
Nold SM
Biochemistry, 56(26), 3358-3368 (2017)

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