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由来生物
mouse
品質水準
結合体
unconjugated
抗体製品の状態
ascites fluid
抗体製品タイプ
primary antibodies
クローン
6D4, monoclonal
含みます
15 mM sodium azide as preservative
化学種の反応性
chicken, Dictyostelium discoideum, bovine, rat
テクニック
western blot: 1:2,000 using a bovine brain calmodulin preparation
アイソタイプ
IgG1
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
rat ... Calm1(24242)
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詳細
Calmodulin belongs to a family of structurally homologous Ca2+-binding proteins. CALM1 gene is located on human chromosome 14q32.11.
Calmodulin is a highly conserved 17kDa calcium binding protein found in all eukaryotic cells. It is a multifunctional molecule. Monoclonal anti-Calmodulin (mouse IgG1 isotype) is derived from the 6D4 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with calmodulin, purified from Dictyostelium discoideum and conjugated to KLH.
特異性
これらの抗体は、それぞれカルモジュリン分子内の異なるエピト-プに対する抗体です。
本抗体は、未変性およびSDS変性カルモジュリンを認識します。
免疫原
細胞性粘菌(Dictyostelium discoideum)由来精製カルモジュリンのKLH結合体。
アプリケーション
Monoclonal Anti-Calmodulin antibody produced in mouse has been used in:
- enzyme-linked immunosorbent assay (ELISA)
- immunoblot
- dot blot
- immunocytochemistry
- immunoprecipitation
- immunofluorescence
生物化学的／生理学的作用
Calmodulin is a ubiquitous molecule which can bind up to 4 calcium ions, regulating and mediating a wide variety of biochemical processes.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
C3545-VAR:
C3545-BULK:
C3545-.2ML:
C J Pallen et al.
The Journal of biological chemistry, 259(10), 6134-6141 (1984-05-25)
Calcineurin possesses phosphatase activity towards both protein (Stewart, A.A., Ingebritsen , T.S., Manalan , A., Klee , C.B., and Cohen, P. (1982) FEBS Lett. 137, 80-84) and nonprotein substrates ( Pallen , C.J., and Wang, J.H. (1983) J. Biol. Chem.
The intellectual disability-associated CAMK2G p. Arg292Pro mutation acts as a pathogenic gain-of-function
Proietti OM, et al.
Human Mutation, 39(12), 2008-2024 (2018)
Identification of calmodulin and MlcC as light chains for Dictyostelium myosin-I isozymes
Crawley SW, et al.
Biochemistry, 50(30), 6579-6588 (2011)
Association between the polymorphisms of CALM1 gene and osteoarthritis risk: a meta-analysis based on observational studies
Yang H, et al.
Bioscience Reports, 38(5), BSR20181128-BSR20181128 (2018)
D Hulen et al.
Cell motility and the cytoskeleton, 18(2), 113-122 (1991-01-01)
Monoclonal antibodies were raised against calmodulin purified from Dictyostelium discoideum. To increase its antigenicity, the calmodulin was conjugated to keyhole limpet hemocyanin; mice were immunized with the conjugate. Hybridomas producing antibodies against calmodulin were identified by screening culture supernatants with
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