C0739

抗コルタクチン, リン酸化型(pTyr⁴²¹)抗体 ウサギ宿主抗体

affinity isolated antibody, buffered aqueous glycerol solution

• MDL番号: MFCD04975269
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: ICC; WB
• クローン: polyclonal
• 化学種の反応性: mouse
• citations: 12
• テクニック: immunocytochemistry: suitable; western blot: 1:1,000

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous glycerol solution
• 分子量: antigen 80-85 kDa
• 化学種の反応性: mouse
• テクニック: immunocytochemistry: suitable; western blot: 1:1,000
• UniProtアクセッション番号: Q60598
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pTyr421)
• 遺伝子情報: mouse ... Cttn(13043)

詳細

詳細

Cortactin is encoded by the CTTN gene on chromosome 11 in humans. It is a cytoskeleton protein that facilitates assembly of cortical actin. It is expressed in most adherent cells and is a prominent substrate of protein-tyrosine kinase Src.

免疫原

マウスコルタクチンのチロシン421がリン酸化された領域に由来する合成リン酸化ペプチド。

アプリケーション

Anti-phospho-Cortactin (pTyr⁴²¹) antibody produced in rabbit is suitable for immunocytochemistry and western blotting at a working dilution of 1:1,000

生物化学的／生理学的作用

Cortactin is activated by phosphorylation of tyrosine kinases or serine/threonine kinases. It plays an important role in promoting lamellipodia formation, invadopodia formation, cell migration, and endocytosis. Cortactin regulates the interactions between components of adherens-type junctions and helps in organizing the cytoskeleton, cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. It acts as a regulator in invasion and migration of tumor cells. The overexpression of cortactin causes osteosarcoma carcinogenesis and along with FAK increases the risk of oral premalignant lesions.

物理的形状

Mg²⁺/Ca²⁺不含D-PBS (pH 7.3 (+/- 0.1), 50%グリセロ-ル, 1.0mg/mL BSA(IgG/プロテア-ゼ不含), 0.05%アジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)