A8800

アルプラゾラム

• 別名: 8-クロロ-1-メチル-6-フェニル-4H-[1,2,4]トリアゾロ[4,3-a][1,4]ベンゾジアゼピン
• 実験式（ヒル表記法）: C₁₇H₁₃ClN₄
• CAS番号: 28981-97-7
• 分子量: 308.76
• EC Number: 249-349-2
• MDL番号: MFCD00078881
• UNSPSCコード: 12352200
• PubChem Substance ID: 24891366
• NACRES: NA.77

特性

• 形状: powder
• 品質水準: 200
• 薬剤管理: USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• 溶解性: H₂O: insoluble; methanol: soluble
• アプリケーション: forensics and toxicology; pharmaceutical (small molecule); veterinary
• オーガナイザー: Johnson & Johnson
• SMILES記法: Cc1nnc2CN=C(c3ccccc3)c4cc(Cl)ccc4-n12
• InChI: 1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3
• InChI Key: VREFGVBLTWBCJP-UHFFFAOYSA-N
• 遺伝子情報: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

詳細

詳細

Alprazolam is a triazole-containing benzodiazepine that is related to diazepam and other 1,4-benxodiazepines. Like other benzodiazepines, Alprazolam is a GABAergic agonist that modulates GABA_A receptors. GABA_A receptors in the central nervous system are ligand-gated ion channels that are bound by the stimulatory neurotransmitter GABA; binding of this ligand allows ion movement through the channel and results in neurotransmission inhibition.

生物化学的／生理学的作用

Alprazolam binds the GABA_A receptor at the benzodiazepine site, which is different than the ligand-binding site at which GABA binds. Alprazolam has been shown to be an anxiolytic (anti-anxiety agent) as well as having anticonvulsant, muscle relaxant and antidepressant activity.

特徴および利点

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves