260M-1

Glycophorin A (GA-R2) Mouse Monoclonal Antibody

• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100; 500
• 結合体: unconjugated
• 抗体製品の状態: culture supernatant
• 抗体製品タイプ: primary antibodies
• クローン: GA-R2, monoclonal
• 詳細: For In Vitro Diagnostic Use in Select Regions (See Chart)
• フォーム: buffered aqueous solution
• 交差性: human
• 包装: vial of 0.1 mL concentrate (260M-14); vial of 0.5 mL concentrate (260M-15); bottle of 1.0 mL predilute (260M-17); vial of 1.0 mL concentrate (260M-16); bottle of 7.0 mL predilute (260M-18)
• メーカー／製品名: Cell Marque^®
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
• アイソタイプ: IgG2bκ
• コントロール: bone marrow
• 輸送温度: wet ice
• 保管温度: 2-8°C
• 視覚化: membranous
• 遺伝子情報: human ... GYPA(2993)

詳細

詳細

Glycophorins A (GPA) and B (GPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and SU blood groups. Glycophorins span the membrane and present their amino-terminal end to the extracellular surface of the human erythrocyte. The genetic array of expressed glycophorin surface antigens on erythrocytes defines the blood group phenotype of the individual. GPA is the carrier of blood group M and N specificities, while GPB accounts for S and U specificities. GPA and GPB provide the cells with a large mucin-like surface and it has been suggested this provides a barrier to cell fusion thus minimizing aggregation between red blood cells in the circulation. Anti-glycophorin A has been used to characterize erythroid cell development and in the diagnosis of erythroid leukemias.

Glycophorins A and B are major sialoglycoproteins expressed across the surface of the human erythrocyte membrane and contain the antigenic determinants that define the MNS blood group system. The high sialic acid content of glycophorin A contributes to the generation of a net negative surface charge across erythrocyte membranes that minimizes interactions between red blood cells and prevents their aggregation. Anti-glycophorin A has utility in identifying cells of the erythroid lineage.

品質

IVD

IVD

IVD

RUO

関連事項

Glycophorin A Positive Control Slides, Product No. 260S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

物理的形状

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

調製ノート

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

その他情報

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法的情報

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany