05288

K-252a

from Nocardiopsis sp.

• 別名: Protein kinase inhibitor
• 実験式（ヒル表記法）: C₂₇H₂₁N₃O₅
• CAS番号: 99533-80-9
• 分子量: 467.47
• MDL番号: MFCD00161522
• UNSPSCコード: 12352200
• PubChem Substance ID: 329747678
• NACRES: NA.85

特性

• 由来生物: Nocardiopsis sp.
• フォーム: powder
• 抗生物質活性スペクトル: viruses
• 作用機序: enzyme | inhibits
• 保管温度: −20°C
• SMILES記法: [H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
• InChI: 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
• InChI Key: KOZFSFOOLUUIGY-SOLYNIJKSA-N
• 遺伝子情報: human ... NTRK1(4914) ; rat ... Prkca(24680)

詳細

アプリケーション

K-252a is used to inhibit protein kinases involved in cell signaling processes, including CaM kinase; phosphorylase kinase, serine/threonine kinases, Trk. It is used to inhibit the actions of nerve growth factor (NGF) on PC1 2 cells and to inhibit smooth muscle myosin light chain kinase .

生物化学的／生理学的作用

Potent inhibitor of various protein kinases including protein kinase A, C, and G. It is is reported to selectively inhibit the actions of nerve growth factor (NGF) on PC1 2 cells and has been shown to inhibit smooth muscle myosin light chain kinase .

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H360D,H371
• 注意書き: P202 - P260 - P264 - P280 - P308 + P311 - P405
• 危険有害性の分類: Repr. 1B - STOT SE 2
• ターゲットの組織: Eyes,Central nervous system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges