PHR1865

（S）-デュロキセチン 塩酸塩

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: LY-248686 塩酸塩, （γS）-N-メチル-γ-（1-ナフタレニルオキシ）-2-チオフェンプロパンアミン 塩酸塩, （+）-N-メチル-3-（1-ナフタレニルオキシ）-3-（2-チエニル）プロパンアミン 塩酸塩, （+）-（S）-N-メチル-γ-（1-ナフチルオキシ）-2-チオフェンプロピルアミン 塩酸塩
• 実験式（ヒル表記法）: C₁₈H₁₉NOS · HCl
• CAS番号: 136434-34-9
• 分子量: 333.88
• MDL番号: MFCD06407958
• UNSPSCコード: 41116107
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to Ph. Eur. Y0001453; traceable to USP 1229817
• APIファミリー: duloxetine
• フォーム: powder
• CofA: current certificate can be downloaded
• 包装: pkg of 500 mg
• アプリケーション: pharmaceutical
• 保管温度: 2-30°C
• SMILES記法: Cl.CNCC[C@H](Oc1cccc2ccccc12)c3cccs3
• InChI: 1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1
• InChI Key: BFFSMCNJSOPUAY-LMOVPXPDSA-N
• 遺伝子情報: human ... SLC6A2(6530) , SLC6A4(6532)

詳細

詳細

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Duloxetine Hydrochloride, a thiophene derivative, belongs to the class of selective serotonin-norepinephrine reuptake inhibitors (SNRI), used for its anti-depressant properties.

アプリケーション

This pharmaceutical secondary standard can also be used as follows:

• Development of two voltammetry methods using carbon paste electrode, for the trace analysis of duloxetine hydrochloride in pharmaceutical dosage forms and human serum samples
• Separation and estimation of curcumin and duloxetine hydrochloride by reversed-phase high-performance liquid chromatography (RP-HPLC) from bulk and pharmaceutical formulations
• Determination of duloxetine in pure form by a UV-Vis spectrophotometric method, in accordance with the ICH Q2R1 guidelines
• Multi-analysis of antidepressant drugs― vilazodone hydrochloride, agomelatine, and duloxetine hydrochloride along with vitamin B12 in their bulk, pharmaceutical formulations, and human urine samples using HPLC

生物化学的／生理学的作用

デュロキセチン塩酸塩はセロトニン／ノルエピネフリンの二重再取込み阻害剤（SNRI）で、抗うつおよび抗不安薬として臨床的に広く使用されています。

デュロキセチン塩酸塩はセロトニン／ノルエピネフリンの二重再取込み阻害剤（SNRI）です。抗うつ剤、抗不安薬。

アナリシスノート

このような2次標準は、入手可能な場合にはUSP、EP、BPの1次標準にマルチトレーサビリティを提供します。

脚注

To see an example of a Certificate of Analysis for this material enter LRAC1689 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

おすすめ製品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P301 + P312 + P330
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable