PHL89262

ケルセチン

phyproof^® Reference Substance

• 別名: 2-(3,4-ジヒドロキシフェニル)-3,5,7-トリヒドロキシ-4H-1-ベンゾピラン-4-オン, 3,3′,4′,5,6-ペンタヒドロキシフラボン
• 実験式（ヒル表記法）: C₁₅H₁₀O₇
• CAS番号: 117-39-5
• 分子量: 302.24
• Beilstein: 317313
• UNSPSCコード: 41116107
• NACRES: NA.24

特性

• グレード: primary reference standard
• 製品種目: phyproof^® Reference Substance
• アッセイ: ≥95.0% (HPLC)
• メーカー／製品名: PhytoLab
• アプリケーション: food and beverages
• フォーマット: neat
• SMILES記法: OC1=CC(O)=C2C(OC(C3=CC=C(O)C(O)=C3)=C(O)C2=O)=C1
• InChI: 1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
• InChI Key: REFJWTPEDVJJIY-UHFFFAOYSA-N

詳細

詳細

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

アプリケーション

• Simultaneous determination of eight arginine-related metabolites in cellular extracts using liquid chromatography-tandem mass spectrometry.: This study utilized the Chromolith^® RP-18 endcapped column to achieve high-resolution separation of arginine-related metabolites in cellular extracts. The method demonstrated excellent reproducibility and sensitivity, highlighting the column′s effectiveness in complex biological sample analysis (Amatya S et al., 2020).


• Rapid Determination of 30 Polyphenols in Tongmai Formula, a Combination of Puerariae Lobatae Radix, Salviae Miltiorrhizae Radix et Rhizoma, and Chuanxiong Rhizoma, via Liquid Chromatography-Tandem Mass Spectrometry.: The Chromolith^® RP-18 endcapped column was employed for the rapid and efficient determination of polyphenols in a traditional Chinese medicine formula. The column′s high throughput and robust performance facilitated the simultaneous analysis of multiple compounds, demonstrating its application in natural product research (Wang FR et al., 2017).


• Simultaneous Liquid Chromatographic Determination of Ebastine with Two Sympathomimetic Drugs Using a Monolithic Column.: This research applied the Chromolith^® RP-18 endcapped column to the simultaneous chromatographic determination of ebastine and two sympathomimetic drugs. The study underscored the column′s ability to provide rapid and efficient separations in pharmaceutical analysis, ensuring accurate quantification of drug components (Ibrahim F et al., 2017).

生物化学的／生理学的作用

ケルセチンは、抗がん活性を有するフラボノイドです。 ケルセチンは、ミトコンドリアのATPaseおよびホスホジエステラーゼの阻害剤です。これは、PI3キナーゼ活性を阻害し、PIPキナーゼ活性をわずかに阻害します。ケルセチンはがん細胞株に対して抗増殖効果を示し、II型エストロゲン受容体を介してがん細胞の増殖を抑え、細胞周期の後期G1期にヒト白血病T細胞を拘束します。 ケルセチンは、脂肪酸シンターゼ活性を阻害する場合もあります。

その他情報

This compound is commonly found in plants of the genus: allium angelica arnica glycyrrhiza hypericum lycium sambucus

法的情報

Chromolith is a registered trademark of Merck KGaA, Darmstadt, Germany

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3