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グレード
analytical standard
品質水準
アッセイ
≥95.0% (HPLC)
シェルフライフ
limited shelf life, expiry date on the label
テクニック
HPLC: suitable
gas chromatography (GC): suitable
mp
150-156 °C
アプリケーション
clinical
フォーマット
neat
保管温度
2-8°C
SMILES記法
O=C(O)C(CC)CC1=C(I)C(N)=C(I)C=C1I
InChI
1S/C11H12I3NO2/c1-2-5(11(16)17)3-6-7(12)4-8(13)10(15)9(6)14/h4-5H,2-3,15H2,1H3,(H,16,17)
InChI Key
OIRFJRBSRORBCM-UHFFFAOYSA-N
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詳細
Iopanoic acid is an oral cholecystographic agent, which is rich in iodine and is a potent inhibitor of 5′-deiodinase.
This radiographic contrast agent prevents the release of thyroid hormone from the thyroid gland. It also inhibits the conversion of thyroxine to triiodothyronine.
This radiographic contrast agent prevents the release of thyroid hormone from the thyroid gland. It also inhibits the conversion of thyroxine to triiodothyronine.
アプリケーション
Iopanoic acid may be used as a standard to investigate the presence and regulation of type 3 iodothyronine deiodinase in human cardiomyocytes.
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Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
14131-BULK:
14131-VAR:
14131-100MG:4548173997025
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Iopanoic acid rapidly controls type I amiodarone-induced thyrotoxicosis prior to thyroidectomy.
Journal of Endocrinological Investigation, 25(2), 176-180 (2002)
Evidence against a major role of L-thyroxine at the pituitary level: studies in rats treated with iopanoic acid (telepaque).
Endocrinology, 106(6), 1827-1836 (1980)
Type 3 iodothyronine deiodinase is expressed in human induced pluripotent stem cell derived cardiomyocytes.
Life Sciences (2018)
The Journal of allergy and clinical immunology, 143(1), 213-228 (2018-03-30)
A delicate balance between cell death and keratinocyte proliferation is crucial for normal skin development. Previous studies have reported that cellular FLICE (FADD-like ICE)-inhibitory protein plays a crucial role in prevention of keratinocytes from TNF-α-dependent apoptosis and blocking of dermatitis.
Nature communications, 11(1), 1613-1613 (2020-04-03)
In men, the incidence of melanoma rises rapidly after age 50, and nearly two thirds of melanoma deaths are male. The immune system is known to play a key role in controlling the growth and spread of malignancies, but whether
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