ABS1036

Anti-FMO3 Antibody

serum, from rabbit

• 別名: Dimethylaniline monooxygenase [N-oxide-forming] 3, Dimethylaniline oxidase 3, FMO form 2, FMO 3, FMO II, Hepatic flavin-containing monooxygenase 3, Trimethylamine monooxygenase
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: serum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 化学種の反応性: human
• 化学種の反応性（ホモロジーによる予測）: chimpanzee (based on 100% sequence homology)
• テクニック: immunohistochemistry: suitable; western blot: suitable
• NCBIアクセッション番号: NP_001002294
• UniProtアクセッション番号: P31513
• 輸送温度: dry ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... FMO3(2328)

詳細

詳細

Dimethylaniline monooxygenase [N-oxide-forming] 3 (EC 1.14.13.8; EC 1.14.13.148; UniProt P31513; also known as Dimethylaniline oxidase 3, FMO form 2, FMO 3, FMO II, Hepatic flavin-containing monooxygenase 3, Trimethylamine monooxygenase) is encoded by the FMO3 (also known as FMOII, TMAU) gene (Gene ID 2328) in human. Flavin-containing mono-oxygenases (FMOs) constitute a family of microsomal chemical- and drug-metabolizing enzymes, with FMO3 being a major form in adult mouse and human liver. FMO3 is responsible for N-oxidation of a malodorous metabolite, trimethylamine (TMA), to the non-odorous trimethylamine N-oxide (TMAO). FMO3 mutations cause trimethylaminuria (TMAU or Fish odor syndrome), a rare inherited disorder due to decreased metabolism of dietary-derived TMA. More than 300 single nucleotide polymorphisms of the human FMO3 have been reported and over 40 of these polymorphisms have been linked to TMAU. 17β-estradiol-dependent ERα activation is reported to play a fundamental role in the regulation of FMO3 gene transcription.

免疫原

Epitope: Internal (N-terminal half).

Linear peptide corresponding to an internal sequence from the N-terminal half of human FMO3.

アプリケーション

Research Category
細胞シグナル伝達

Research Sub Category
トキシコロジー及び薬剤抵抗性

Detect FMO3 using this Anti-FMO3 Antibody validated for use in Western Blotting, Immunohistochemistry.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FMO3 in human liver tissue.

品質

Evaluated by Western Blotting in human liver microsomal tissue lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected FMO3 in 10 µg of human liver microsomal tissue lysate.

ターゲットの説明

~55 kDa observed. 59.96 kDa calculated.

物理的形状

Unpurified

Rabbit polyclonal serum with 0.05% sodium azide.

保管および安定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable