FMO3
flavin containing monooxygenase 3
Synonyms:
FMOII, TMAU, dJ127D3.1
Species:
Human FMO3 (2328), Mouse Fmo3 (14262), Rat Fmo3 (84493), dog FMO3 (403603), domestic cat FMO3 (101089484), cow FMO3 (281167), sheep FMO3 (101104165), Domestic Rabbit FMO3 (100009065), naked mole-rat Fmo3 (101711325), domestic guinea pig Fmo3 (100727520)
UniProtKB ID:
Gene ID:
- Human(2328) Summary: Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Aug 2009]
- Mouse(14262) flavin containing monooxygenase 3
- Rat(84493) flavin containing monooxygenase 3
- dog(403603) flavin containing monooxygenase 3
- domestic cat(101089484) flavin containing monooxygenase 3
- cow(281167) flavin containing monooxygenase 3
- sheep(101104165) flavin containing monooxygenase 3
- Domestic Rabbit(100009065) flavin containing monooxygenase 3
- naked mole-rat(101711325) flavin containing monooxygenase 3
- domestic guinea pig(100727520) flavin containing monooxygenase 3
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-FMO3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, human, pig, rat
Application
immunohistochemistry
western blot
western blot
Anti-FMO3 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Anti-FMO3 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-FMO3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-FMO3 Antibody, clone 6Q10X9, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunofluorescence
western blot
western blot
Proteins
Product Number
Description
Species
Flavin-Containing Monooxygenase-3, Microsomes human, recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution,
Species
human