ABC517

Anti-PGAM5 Antibody

from rabbit, purified by affinity chromatography

• 別名: Serine/threonine-protein phosphatase PGAM5, mitochondrial, Bcl-XL-binding protein v68, Phosphoglycerate mutase family member 5
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: human
• 化学種の反応性（ホモロジーによる予測）: primate (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), rodent (based on 100% sequence homology), monkey (based on 100% sequence homology), hamster (based on 100% sequence homology)
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_001164014
• UniProtアクセッション番号: Q96HS1
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... PGAM5(192111)

詳細

詳細

PGAM5 is a mitochondrial specific phosphatase specific for serine/threonine residues. PGAM5 principally dephosphorylates and activates MAP3K5 kinase a critical player in many cancers. PGAM5 also acts as a central mediator for programmed necrosis or necroptosis, induced by TNF, ROS or calcium. In the mitochondria, PGAM5 may also function as a regulator of mitochondrial dynamics and reconstruction. Also PGAM5 functions in the cellular stress response and regulates the removal of damaged mitochondria via mitophagy. PGAM5 itself is regulated at the protein level by the mitochondrial specific rhomboid protease PARL, which cleaves the N-terminal of PGAM5 in response to mitochondrial depolarization.

特異性

This antibody detects the -L(long) isoform and -S(short) isoform of PGAM5.

免疫原

Epitope: Near N-terminal

KLH-conjugated linear peptide corresponding to human PGAM5 near the N-terminal.

アプリケーション

Research Category
アポトーシス及び癌

Research Sub Category
アポトーシス-追加

This Anti-PGAM5 Antibody is validated for use in Western Blotting for the detection of PGAM5.

品質

Evaluated by Western Blotting in HT-29 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected PGAM5 in 10 µg of HT-29 cell lysate.

ターゲットの説明

~32/34 kDa observed.

物理的形状

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable