AB2959

Anti-ADAM 9 Antibody, disintegrin domain

from rabbit

• 別名: ADAM metallopeptidase domain 9 (meltrin gamma), a disintegrin and metalloproteinase domain 9 (meltrin gamma), Cellular disintegrin-related protein, Myeloma cell metalloproteinase, Metalloprotease/disintegrin/cysteine-rich protein 9
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: purified antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 化学種の反応性: human
• 化学種の反応性（ホモロジーによる予測）: chimpanzee (based on 100% sequence homology), primate (based on 100% sequence homology)
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_003807
• UniProtアクセッション番号: Q13443
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ADAM12(8038) , ADAM9(8754)

詳細

詳細

A disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) belongs to a family of transmembrane, membrane-anchored, disintegrin-containing proteins that are involved in several biological functions such as protein ectodomain shedding, cell fusion, and cell adhesion. ADAMs contain several characteristic domains, two of which, the protease and disintegrin domains, are noted for their homology to snake venom metalloprotease. The exact function of ADAM 9 is yet unknown, however it is widely distributed, is found within keratinocytes, and is ideally placed on the cell membrane, which some studies have suggested supports a role in cell migration and motility. Alternative splicing results in two isoforms; isoform 1 is found within the cell membrane and is considered a single-pass type 1 membrane protein, while isoform 2 is secreted. Mutations in ADAM 9 expression are causal to cone-rod dystrophy type 9 or CORD9 which is characterized by visible retinal pigment deposits and loss of cone photoreceptors leading and rod degeneration, ultimately resulting in severe loss of vision.

特異性

Mouse and rat (90% sequence homology).

免疫原

Epitope: disintegrin domain

KLH-conjugated linear peptide corresponding to the disintegrin domain of human ADAM 9.

アプリケーション

Research Category
細胞骨格

Research Sub Category
MMP及び組織メタロプロテアーゼ

Detect ADAM 9 using this Anti-ADAM 9 Antibody, disintegrin domain validated for use in WB.

品質

Evaluated by Western Blot in human chondrocyte cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected ADAM 9 in 10 µg of human chondrocyte cell lysate.

ターゲットの説明

~ 90 kDa observed. 2 isoforms are produced by alternative splicing: Isoform 1 at 91 kDa and Isoform 2 at 72 kDa

関連事項

Replaces: AB19025

物理的形状

Protein A purified

Format: Purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
Human chondrocyte cell lysate

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable