AB2285

Anti-Glutamate Receptor Delta 1/2 Antibody

from rabbit, purified by affinity chromatography

• 別名: GluR delta-1, glutamate receptor, ionotropic, delta 1
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: rat, mouse, primate, human
• テクニック: western blot: suitable
• NCBIアクセッション番号: NM_017551.2
• UniProtアクセッション番号: Q9ULK0
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... GRID1(2894)

詳細

詳細

The majority of rapid excitatory transmission in the nervous system is mediated by glutamate-activated ion channels. Ionotropic glutamate receptors have been subdivided pharmacologically into AMPA (cx-amino-3-hydroxy-5methyl-Cisoxazole propionic acid), KA (kainate), and NMDA subtypes (Monaghan et al., 1989). These receptors have been implicated in a number of physiological and pathological processes. During development glutamate receptors are involved in neuronal differentiation, migration, and activity-dependent synapse formation (Balazs et al., 1989; Brewer, 1989; Komoru and Rakic, 1993). In mature neurons, long-term potentiation and long-term depression require ionotropic glutamate receptors. Glutamate-gated ion channels also play a central role in mediating the excitotoxic effects of glutamate (Olney, 1990). Pathophysiological processes thought to involve glutamate excitotoxicity and neurodegeneration include epilepsy stroke, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis.

特異性

Cat. # AB2285 reacts with the C-Terminus of Glutamate Receptor Delta 1/2.

Reacts weakly with mouse. May react with Primate based on sequence homology. Reactivity with other species has not been tested.

免疫原

Epitope: C-Terminus, Cytoplasmic

Synthetic linear peptide to the C-Terminus, conjugated to BSA.

アプリケーション

Research Category
ニューロサイエンス

Research Sub Category
神経伝達物質及び受容体

Anti-Glutamate Receptor Delta 1/2 Antibody detects level of Glutamate Receptor Delta 1/2 & has been published & validated for use in WB.

Western Blotting:
Human Cerebellum Lysate.

品質

Western Blotting: 1:5,000 dilution from a previous lot detected Glutamate Receptor Delta 1/2 on 10 µg of rat or human cerebellum lysate.

ターゲットの説明

~114 kDa

物理的形状

Antigen Affinity Purified

Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.

保管および安定性

Stable for 1 year at 2-8ºC from date of receipt.

アナリシスノート

Control
Rat cerebellum tissue lysate and human cerebellum tissue lysate.

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable