8.51095

PyOxim

≥99.0% (HPLC), for peptide synthesis, Novabiochem^®

• 別名: PyOxim, 1-Cyano-2-ethoxy-2-oxoethylideneaminooxy-tris-pyrrolidino-phosphonium hexafluorophosphate
• 実験式（ヒル表記法）: C₁₇H₂₉F₆N₅O₃P₂
• CAS番号: 153433-21-7
• 分子量: 527.38
• MDL番号: MFCD18643381
• UNSPSCコード: 12352126
• NACRES: NA.22

特性

• 製品名: PyOxim, Novabiochem^®
• 品質水準: 300
• 製品種目: Novabiochem^®
• アッセイ: ≥99.0% (HPLC)
• フォーム: powder
• 反応適合性: reaction type: Coupling Reactions
• メーカー／製品名: Novabiochem^®
• アプリケーション: peptide synthesis
• 保管温度: 15-25°C
• SMILES記法: F[P-](F)(F)(F)(F)F.[P](=[N+]3CCCC3)(N2CCCC2)(N1CCCC1)O\N=C(\C(=O)OCC)/C#N
• InChI: 1S/C17H29N5O3P.F6P/c1-2-24-17(23)16(15-18)19-25-26(20-9-3-4-10-20,21-11-5-6-12-21)22-13-7-8-14-22;1-7(2,3,4,5)6/h2-14H2,1H3;/q+1;-1/b19-16+;
• InChI Key: RDWDVLFMPFUBDV-PXMDEAMVSA-N

詳細

詳細

PyOxim ^[1] is a novel reagent which mediates coupling reactions with efficiencies superior to HATU and PyBOP and comparable to COMU. It is has excellent solubility in DMF and is stable in solution under an inert atmosphere for two days. Unlike HATU and HBTU, it cannot cause chain terminating side reactions and is, therefore, ideal for the synthesis of cyclic peptides. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents.


Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] R. Subiros-Funosas, et al. (2010) Org. Biomol. Chem., 8, 3665.

特徴および利点

• Mediates coupling with superior efficiency to PyBOP, TBTU, and HCTU
• Mediates coupling with low racemization or epimerization
• Ideal for fragment condensation and synthesis of cyclic peptides as the reagent cannot cause guanidinylation
• Excellent solubility in DMF and NMP

アナリシスノート

Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 %
Solubility (1 mmole in 2 ml DMF): clearly soluble

法的情報

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable