8.51085

COMU

≥99.0% (HPLC), for peptide synthesis, Novabiochem^®

• 別名: COMU, 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino-morpholino)] uronium hexafluorophosphate
• 実験式（ヒル表記法）: C₁₂H₁₉F₆N₄O₄P
• CAS番号: 1075198-30-9
• 分子量: 428.27
• MDL番号: MFCD11975052
• UNSPSCコード: 12352107
• NACRES: NA.22

特性

• product name: COMU, 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy) dimethylaminomorpholino)] uronium hexafluorophosphate Novabiochem^®
• 品質水準: 300
• 製品種目: Novabiochem^®
• アッセイ: ≥99.0% (HPLC)
• 形状: powder
• 反応適合性: reaction type: Coupling Reactions
• メーカー／製品名: Novabiochem^®
• mp: >140 °C
• アプリケーション: peptide synthesis
• 保管温度: 15-25°C
• InChI: 1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;
• InChI Key: GPDHNZNLPKYHCN-DZOOLQPHSA-N

詳細

詳細

COMU is a novel reagent which mediates coupling reactions with efficiencies comparable to HATU ^[1,2].It has higher solubility than HATU and HBTU. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents. Recently, the application of COMU in the preparation of esters has been demonstrated ^[3].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] A. El-Faham, et al. (2009) Chem. Eur. J., 15, 9404.
^[2] A. El-Faham & F. Albericio (2010) J. Pept. Sci., 16, 6.
^[3] Jean-d′Amour, et al. (2011) Org. Lett., 13, 2988.

アプリケーション

• Re-evaluating the stability of COMU in different solvents: This study highlights the robust stability and effectiveness of COMU, promoting its use in various peptide synthesis scenarios, enhancing both scalability and environmental friendliness (Kumar et al., 2017).

アナリシスノート

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (10% in acetonitrile): clear

法的情報

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable