8.51221

PyAOP

for peptide synthesis, Novabiochem^®

• 別名: PyAOP, (7-Azabenzotriazol-1-yloxy)trispyrrolidinophosphonium hexafluorophosphate
• 実験式（ヒル表記法）: C₁₇H₂₇F₆N₇OP₂
• CAS番号: 156311-83-0
• 分子量: 521.38
• MDL番号: MFCD03703417
• UNSPSCコード: 12352101
• NACRES: NA.22

特性

• product name: PyAOP, Novabiochem^®
• 品質水準: 200
• 製品種目: Novabiochem^®
• 形状: powder
• 反応適合性: reaction type: Coupling Reactions
• メーカー／製品名: Novabiochem^®
• アプリケーション: peptide synthesis
• 保管温度: 15-25°C
• InChI: 1S/C17H27N7OP.F6P/c1-2-11-21(10-1)26(22-12-3-4-13-22,23-14-5-6-15-23)25-24-17-16(19-20-24)8-7-9-18-17;1-7(2,3,4,5)6/h7-9H,1-6,10-15H2;/q+1;-1
• InChI Key: CBZAHNDHLWAZQC-UHFFFAOYSA-N

詳細

詳細

PyAOP is an extremely effective coupling reagent that mediates amide bond formation with the efficiency of HATU but without the risk of guanidine formation, making it the reagent of choice for peptide cyclization.

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references:
^[1] F. Albericio, et al. (1997) Tetrahedron Lett., 38, 4853.

アプリケーション

PyAOP can be used as a coupling reagent:

• In the synthesis of N,N′-substituted acylguanidines by solid-phase peptide synthesis.
• To facilitate the formation of peptide bonds during the synthesis of cyclic peptide hybrids.

アナリシスノート

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

法的情報

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315 - H319 - H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable