8.51090

TFFH

Tetramethylfluoroformamidinium hexafluorophosphate Novabiochem^®

• 別名: TFFH, Tetramethylfluoroformamidinium hexafluorophosphate,Fluoro-N,N,N′,N′-bis(tetramethylene)formamidinium hexafluorophosphate
• 実験式（ヒル表記法）: C₅H₁₂F₇N₂P
• CAS番号: 164298-23-1
• 分子量: 264.12
• MDL番号: MFCD02684443
• UNSPSCコード: 12352107
• NACRES: NA.22

特性

• 品質水準: 200
• 製品種目: Novabiochem^®
• 形状: solid
• 反応適合性: reaction type: Coupling Reactions
• メーカー／製品名: Novabiochem^®
• mp: 104-109 °C
• アプリケーション: peptide synthesis
• 保管温度: 2-8°C
• InChI: 1S/C5H12FN2/c1-7(2)5(6)8(3)4/h1-4H3/q+1
• InChI Key: JILUGXGJYPRQPA-UHFFFAOYSA-N

詳細

詳細

TFFH is an in situ coupling reagents which smoothly converts protected amino acids to the corresponding acid fluoride in the presence of base ^[1]. Acid fluorides have proven are highly effective at coupling hindered amino acids such as α,α-disubstituted amino acids ^[2].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] L. A. Carpino, et al. (1995) J. Am. Chem. Soc., 117, 5401.
^[2] S. A. Triolo, et al. in ′Peptides 1996, Proc. of 24th European Peptide Symposium′, R. Ramage & R. Epton (Eds), Mayflower Scientific Ltd., Birmingham, 1998, pp. 839.

アナリシスノート

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Assay 1H-qNMR: ≥ 98.0 %
Ratio Cation/anion in 19F-NMR integration: lot specific result
1:5,7 to 1:6,3
Identity (IR): passes test

法的情報

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS05,GHS07
• シグナルワード: Danger
• 危険有害性情報: H315 - H318 - H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable