682160-M

Xestospongin C, Xestospongia sp.

An oxaquinolizidine alkaloid isolated from a marine sponge.

• 別名: Xestospongin C, Xestospongia sp., XeC
• 実験式（ヒル表記法）: C₂₈H₅₀N₂O₂
• 分子量: 446.71
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: film
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white to off-white
• 溶解性: DMSO: 1 mg/mL; ethanol: 1 mg/mL; methanol: 1 mg/mL
• 保管温度: −20°C

詳細

詳細

A macrocyclic bis-1-oxaquinolizidine natural product isolated from a marine sponge. A very potent, reversible and membrane-permeable blocker of IP₃-mediated Ca²⁺ release (IC₅₀ = 358 nM) that does not interact with the IP₃-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (Ry₁R). Also blocks bradykinin- and carbamylcholine-induced Ca²⁺ efflux from the ER stores in a reversible manner.

An oxaquinolizidine alkaloid isolated from a marine sponge. A very potent, reversible, and membrane-permeable blocker of IP₃-mediated Ca²⁺ release (IC₅₀ = 358 nM) that does not interact with the IP₃-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1). Also blocks bradykinin- and carbamylcholine-induced Ca²⁺ efflux from the endoplasmic reticulum stores in a reversible manner.

生物化学的／生理学的作用

Primary Target
IP3-mediated Ca2+ release

Target IC₅₀: 358 nM in blocking IP3-mediated Ca2+ release

警告

Toxicity: Harmful (C)

調製ノート

Sonication may be required to achieve complete solubilization.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Oka, T., et al. 2002. Br. J. Pharmacol.135, 1959.
Gafni, J., et al. 1997. Neuron 19, 723.
Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
Nakagawa, M., et al. 1984. Tetrahedron Lett.25, 3227.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable