677175-M

Vinblastine Sulfate

Antitumor alkaloid drug.

• 別名: Vinblastine Sulfate
• 実験式（ヒル表記法）: C₄₆H₅₈N₄O₉ · xH₂SO₄
• CAS番号: 143-67-9
• 分子量: 810.97 (free base basis)
• MDL番号: MFCD00082457
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: crystalline solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated; protect from light
• 色: white
• 溶解性: water: 50 mg/mL
• 保管温度: 2-8°C
• InChI: 1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
• InChI Key: KDQAABAKXDWYSZ-JKDPCDLQSA-N

詳細

詳細

Antitumor alkaloid drug. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Affects interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2. Depolymerizes microtubules. Increases frequency of micronucleated erythrocytes.

Antitumor alkaloid drug. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Affects interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2. Depolymerizes microtubules. Increases the frequency of micronucleated erythrocytes.

生物化学的／生理学的作用

Primary Target
Interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Tanaka, E., et al. 1995. J. Cell. Biol.128, 139.
Boscoboinik, D., et al. 1994. Biochem. Biophys. Res. Commun.199, 374.
Smith, C.D., et al. 1994. Cancer Lett.79, 213.
Smith, C.D., et al. 1994. Cancer Res.54, 3779.
Tsukidate, K., et al. 1993. Am. J. Pathol. 143, 198.
Jagetia, G.C., and Jacob, P.S. 1992. Mutat. Res.280, 87.
Jordan, M.A., et al. 1992. J. Cell Sci. 102, 401.
Prasad, V., et al. 1992. J. Protein Chem.11, 509.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H341,H361fd
• 注意書き: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• 危険有害性の分類: Acute Tox. 4 Oral - Muta. 2 - Repr. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3