676492

VEGFR3 Kinase Inhibitor, MAZ51

The VEGFR3 Kinase Inhibitor, MAZ51, also referenced under CAS 163655-37-6, controls the biological activity of VEGFR3 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: VEGFR3 Kinase Inhibitor, MAZ51, MAZ51, 3-(4-Dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one, Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XVI, VEGFR3 Kinase Inhibitor I
• 実験式（ヒル表記法）: C₂₁H₁₈N₂O
• CAS番号: 163655-37-6
• 分子量: 314.38
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: red
• 溶解性: DMSO: 10 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C21H18N2O/c1-23(2)20-12-11-14(15-7-3-4-9-17(15)20)13-18-16-8-5-6-10-19(16)22-21(18)24/h3-13H,1-2H3,(H,22,24)
• InChI Key: VFCXONOPGCDDBQ-UHFFFAOYSA-N

詳細

詳細

A cell-permeable 3-substituted indolin-2-one compound that acts as a reversible and ATP-competitive VEGF receptor tyrosine kinase inhibitor. At low concentration (≤5 µM), it specifically blocks VEGF-C- (Cat. No. 676476) and VEGF-D- (Cat. No. 676471) induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 µM). This differential blocker may be useful for inhibiting lymphangiogenesis-dependent pathological process such as tumor metastasis. Not available for sale in Germany.

A cell-permeable, 3-substituted, indolin-2-one compound that acts as a reversible and ATP-competitive inhibitor of VEGF receptor tyrosine kinase. At low concentrations (5 µM), reported to specifically block VEGF-C and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. Reported to partially block VEGFR-2 phosphorylation only at higher concentrations (50 µM). This differential inhibition may be useful for controlling lymphangiogenesis-dependent tumor metastasis and could, therefore, be of clinical significance for cancer therapy studies.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
VEGF receptor tyrosine kinase

Product competes with ATP.

Reversible: yes

Target IC₅₀: At low concentration (≤5 µM), it specifically blocks VEGF-C- and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

その他情報

Kirkin, V., et al. 2001. Eur. J. Biochem.268, 5530

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3