552233

QX-314

≥99% (HPLC), lyophilized solid, voltage-sensitive Na+ conductance blocker, Calbiochem^®

• 別名: QX-314
• 実験式（ヒル表記法）: C₁₆H₂₇BrN₂O
• CAS番号: 21306-56-9
• 分子量: 343.30
• MDL番号: MFCD00083182
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 製品名: QX-314, A quaternary lidocaine derivative, permanently charged, and lipophobic.
• 品質水準: 100
• アッセイ: ≥99%
• フォーム: lyophilized solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 溶解性: water: 3 mg/mL
• 輸送温度: ambient
• 保管温度: 10-30°C
• SMILES記法: [N+](CC)(CC)(CC)CC(=O)Nc1c(cccc1C)C
• InChI: 1S/C16H26N2O/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5/h9-11H,6-8,12H2,1-5H3/p+1
• InChI Key: PYEBKOFMWAMBFV-UHFFFAOYSA-O

詳細

詳細

A quaternary lidocaine derivative, permanently charged, and lipophobic. A powerful blocker of voltage-sensitive Na⁺ conductance when applied intracellularly. Suppresses the generation of Na⁺-dependent spikes from inside the cell membrane, without affecting Ca²⁺ currents or glutamate-activated currents.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
A powerful blocker of voltage-sensitive Na+ conductance

Product does not compete with ATP.

Reversible: no

fully active in neurophysiological testing

警告

Toxicity: Irritant (B)

その他情報

Mooney, R. 1992. J. Neurosci.12, 2464.
Regehr, W.G. and Tank, D.W. 1992. J. Neurosci.12, 4202.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable