487957

NOC-18

A nitric oxide (NO) donor similar to NOC-5, NOC-7 and NOC-12 but with an enhanced half-life.

• 別名: NOC-18, DETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino) bis-ethanamine, DETA NONOate, DETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate
• 実験式（ヒル表記法）: C₄H₁₃N₅O₂
• CAS番号: 146724-94-9
• 分子量: 163.18
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥90% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 色: white
• 溶解性: PBS, pH 7.4: 100 mg/mL; 10 mM NaOH: soluble; water: soluble
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C4H13N5O2/c5-1-3-8(4-2-6)9(11)7-10/h11H,1-6H2/p+2
• InChI Key: HMRRJTFDJAVRMR-UHFFFAOYSA-P

詳細

詳細

A nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952) and NOC-12 (Cat. No. 487955) but with an enhanced half-life. Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu²⁺in vitro. Half-life (t_½) in PBS, pH 7.4 is 3400 minutes at 22°C. Relatively stable in alkaline solution (pH ≥10.0).

A nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952), and NOC-12 (Cat. No. 487955) but with enhanced half-life for NO release (t_½ = 3400 min; PBS, pH 7.4, 22°C). Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu²⁺in vitro.

生物化学的／生理学的作用

Cell permeable: no

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Irritant (B)

再構成

Following reconstitution in NaOH, aliquot and freeze (-20°C). Stock solutions in NaOH are stable for up to 24 h at -20°C. Stock solutions in H₂O or PBS, pH 7.4 are unstable; reconstitute just prior to use.

その他情報

Seccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306.
Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103.
Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519.
Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287.
Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10-13 - German Storage Class 10 to 13