217386

Carboxy-PTIO, Sodium Salt

Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2⁻/NO3⁻ with a rate constant of 1 x 10⁴ M⁻¹sec⁻¹.

• 別名: Carboxy-PTIO, Sodium Salt, 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, Na
• 実験式（ヒル表記法）: C₁₄H₁₆N₂O₄ · Na
• 分子量: 299.28
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (TLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 色: dark blue
• 溶解性: HEPES Buffer: 0.4 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

Reacts with nitric oxide at pH 7.4, resulting in the generation of NO₂^-/NO₃^- with a rate constant of 1 x 10⁴ M^-1sec^-1. Prevents SIN-1 induced endothelial cell death. Has potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.

Reacts with nitric oxide at pH 7.4, resulting in the generation of NO₂^-/NO₃^- with a rate constant of 1 x 10⁴ M^-1sec^-1. Prevents SIN-1 induced endothelial cell death. Reported to have potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Nitric oxide scavenging action

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 1 week at 4°C.

その他情報

Ishii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
Amano, F., and Nova, J. 1995. FEBS Lett.368, 425.
Hogg, N., et al. 1995. Free Radical Res.22, 47.
Az-ma, T., et al. 1994. Life Sci.54, 185.
Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun.202, 923.
Akaike, T., et al. 1993. Biochemistry32, 827.
Yoshida, K., et al. 1993. Infect. Immun.61, 3552.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable