376817-M

Hexokinase II Inhibitor II, 3-BP

The Hexokinase II Inhibitor II, 3-BP, also referenced under CAS 1113-59-3, controls the biological activity of Hexokinase II. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 別名: Hexokinase II Inhibitor II, 3-BP, 3-BrPA, Bromopyruvate, Bromopyruvatic Acid, 3-Bromo-2-oxopropionic acid
• 実験式（ヒル表記法）: C₃H₃BrO₃
• CAS番号: 1113-59-3
• 分子量: 166.96
• MDL番号: MFCD00002587
• UNSPSCコード: 12352200
• EC Index Number: 214-206-5

特性

• 品質水準: 100
• アッセイ: ≥97% (titration)
• 形状: crystalline solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white
• 溶解性: DMSO: 100 mg/mL; distilled water: 100 mg/mL
• 保管温度: 2-8°C
• InChI: 1S/C3H3BrO3/c4-1-2(5)3(6)7/h1H2,(H,6,7)
• InChI Key: PRRZDZJYSJLDBS-UHFFFAOYSA-N

詳細

詳細

A cell-permeable pyruvic acid derivative that acts as an inhibitor against hexokinase II-mediated glycolysis and effectively suppress tumor survival both in cultures in vitro and in mice and rats in vivo.

警告

Toxicity: Corrosive (L)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Bujis, M., et al. 2009. Invest. New Drugs27, 120.
Chen, Z., et al. 2009. Biochim. Biophys. Acta.1787, 553.
Hulleman, E., et al. 2009. Blood.113, 2014;
Mathupala, S.P., et al. 2009. Semin. Cancer Biol.19, 17.
Pereira da Silva, A.P., et al. 2009. Biochem. J.417, 717.
Yun, J., et al. 2009. Science.325, 1555.
Zhang, X., et al. 2009. Anticancer Res.29, 1443.
Kim, J.S., et al. 2008. J. Bioenerg. Biomembr.40, 607.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS05
• シグナルワード: Danger
• 危険有害性情報: H314
• 注意書き: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• 危険有害性の分類: Eye Dam. 1 - Skin Corr. 1B
• 保管分類コード: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable