252750

Deferoxamine Mesylate

Iron chelating agent

• 別名: Deferoxamine Mesylate, Desferrioxamine Mesylate, DFOM, Iron Chelator II
• 実験式（ヒル表記法）: C₂₅H₄₈N₆O₈ · xCH₄O₃S
• CAS番号: 138-14-7
• 分子量: 560.68 (free base basis)
• MDL番号: MFCD00058605
• UNSPSCコード: 41116107
• NACRES: NA.25

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 反応適合性: reagent type: chelator
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: faint yellow
• 溶解性: water: 50 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
• InChI Key: IDDIJAWJANBQLJ-UHFFFAOYSA-N

詳細

詳細

Iron chelating agent. Completely protects against dopamine-induced cell death. Has also been shown to interfere with hydroxyl radical formation, which mediates tissue damage in several disease states. Shows anti-proliferative effect on vascular smooth muscle cells in vitro and in vivo. Can also inhibit the oxidative chemistry of peroxynitrite by reaction of the hydroxamic acid moieties with trans-peroxynitrous acid.

アプリケーション

• Defective ferritinophagy and imbalanced iron metabolism in PBDE-47-triggered neuronal ferroptosis and salvage by Canolol.: This study explores the application of Deferoxamine Mesylate in mitigating iron overload and oxidative stress in neuronal cells, demonstrating its potential in neuroprotection and treatment strategies for neurodegenerative disorders (Wang et al., 2024).


• Ferroptosis resists intracellular Vibrio splendidus AJ01 mediated by ferroportin in sea cucumber Apostichopus japonicus.: The study demonstrates the potential of Deferoxamine Mesylate in aquatic animal health, particularly in enhancing the resistance against bacterial infections by modulating ferroptosis pathways (Wang et al., 2024).

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

その他情報

Bergeron, R.J., et al. 1996. J. Med. Chem. 39, 1575.
Ben-Shachar, D., et al. 1995. J. Neurochem. 64, 718.
Denicola, A., et al. 1995. Free Radic. Biol. Med. 19, 11.
Dzwigaj, S., and pererat, H., 1995. Free Radic. Res.14, 103.
Dang, S., et al. 1994. Res. Commun. Mol. Pathol. Pharmacol. 86, 43.
Porreca, E., et al. 1994. Arterioscler. Thromb. 14, 299.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable