203695

bpV(phen)

A potent protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator.

• 別名: bpV(phen), Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (V), PTEN Inhibitor I, PTP Inhibitor VIII
• 化学式: K[VO(O₂)₂C₁₂H₈N₂]
• CAS番号: 42494-73-5
• MDL番号: MFCD32671691
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥99% (⁵¹V-NMR)
• フォーム: solid
• 有効性: 38 nM IC₅₀
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: yellow
• 溶解性: water: 5 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: [V]=O.[K+].n1c2c3ncccc3ccc2ccc1.OO.OO
• InChI: 1S/C12H8N2.K.2H2O2.O.V/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;2*1-2;;/h1-8H;;2*1-2H;;/q;+1;;;;
• InChI Key: MQPXOTNOFVCXDA-UHFFFAOYSA-N

詳細

詳細

A potent insulin receptor kinase (IRK) activator and protein phosphotyrosine phosphatase inhibitor. Excellent insulin mimetic for in vitro and in vivo use (15 µg/kg). Inhibits in situ dephosphorylation of autophosphorylated insulin receptors with greater than 1000-fold potency over sodium orthovanadate. Arrests proliferation of neuroblastoma NB 41 and glioma C6 cells at the G₂/M transition of the cell cycle. Also reported to potently inhibit PTEN (IC₅₀ = 38 nM). The water content varies from lot to lot and is supplied on the label along with the lot-specific molecular weight.

A potent protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator. Excellent insulin mimetic at 15 µg/kg in vitro and in vivo for use. Inhibits the in situ dephosphorylation of autophosphorylated insulin receptors with over 1000-fold greater potency than sodium orthovanadate. Arrests proliferation of neuroblastoma NB 41 and glioma C6 cells at the G₂/M transition of the cell cycle. Also reported to potently inhibit PTEN (IC₅₀ = 38 nM).

The water content varies from lot to lot and is supplied on the label along with the lot-specific molecular weight.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
PTEN

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Unstable in solution; reconstitute just prior to use.

その他情報

Schmid, A.C., et al. 2004. FEBS Lett.566, 35.
Muzyamba, M.C., et al. 1999. J. Physiol. 517, 421.
Drake, P.G., et al. 1996. Endocrinology137, 4960.
Bevan, A.P., et al. 1995. Am. J. Physiol.268, E60.
Bevan, A.P., et al. 1995. J. Biol. Chem. 270, 10784.
Yale, J.F., et al. 1995. Diabetes 44, 1274.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable