SML0884

bpV(HOpic)

≥90% V basis

• 別名: Bisperoxovanadium(HOpic), Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V), K₂[VO(O₂)2C₆H₄NO₃]
• 実験式（ヒル表記法）: K₂VOO₂O₂C₆H₄NO₃
• CAS番号: 722494-26-0
• 分子量: 347.24
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥90% V basis
• 形状: powder
• 保管条件: desiccated; protect from light
• 色: faintly yellow to dark yellow
• 溶解性: H₂O: 20 mg/mL, clear
• 保管温度: −20°C

詳細

アプリケーション

bpV(HOpic) has been used in pharmacological perturbation of cell migration related signaling pathway.

生物化学的／生理学的作用

bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC₅₀ values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 μM for PTPβ and 25.3 μM for PTP-1β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury.

その他情報

Soluble in DMSO or water. NOTE: The product is not stable in water. Decomposition starts immediately after solubilization. Rate of decomposition is slower in dry DMSO.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319
• 注意書き: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable