14-548-M

MSK1 Protein, active, 10 µg

Active, N-terminal His6-tagged recombinant human MSK1 residues 2-end, for use in Kinase Assays.

• UNSPSCコード: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

特性

• 由来生物: human
• 品質水準: 100
• リコンビナント: expressed in baculovirus infected Sf21 cells
• 製品種目: Upstate^®
• 比活性: (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
• 分子量: M_w 94 kDa
• 精製方法: (Ni²⁺/NTA-agarose)
• 化学種の反応性: human
• メーカー／製品名: Upstate^®
• テクニック: activity assay: suitable (kinase)
• アクセッション番号: (FUNCTION: SwissProt: O75582 # Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of ′Ser-1′ of histone H2A. Phosphorylates ′Ser-10′ of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate ′Ser-28′ of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14). ); NM_004755.2
• NCBIアクセッション番号: NM_004755.2; NM_182398.1
• UniProtアクセッション番号: O75582
• 関連疾患: metabolic disorders; cardiovascular diseases
• 遺伝子情報: human ... RPS6KA5(9252)

詳細

詳細

N-terminal His6-tagged recombinant human MSK1 residues 2-end

アプリケーション

Research Category
代謝

Research Sub Category
心血管疾患

代謝障害

生物化学的／生理学的作用

Protein Target: MSK1

Target Sub-Family: AGC

包装

Also available in 10 μg size and in bulk

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-548M when ordering the 250 µg size.

品質

routinely evaluated by phosphorylation of Crosstide

ターゲットの説明

MSK1

物理的形状

Ni²⁺/NTA-agarose

保管および安定性

6 months at -20°C

その他情報

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法的情報

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H317
• 注意書き: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危険有害性の分類: Skin Sens. 1
• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1