1.00894

スクラロース

powder, EMPROVE^® ESSENTIAL, Ph. Eur., ChP, JPE, NF

• 別名: 1,6-ジクロロ-1,6-ジデオキシ-β-D-フルクトフラノシル-4-クロロ-4-デオキシ-α-D-ガラクトピラノシド, E955, トリクロロスクロース
• 実験式（ヒル表記法）: C₁₂H₁₉Cl₃O₈
• CAS番号: 56038-13-2
• 分子量: 397.63
• Beilstein: 3654410
• MDL番号: MFCD03648615
• UNSPSCコード: 12352121
• EC Index Number: 259-952-2

特性

• 認証: ChP; JPE; NF; Ph. Eur.
• 品質水準: 500
• 詳細: EMPROVE^® ESSENTIAL Ph Eur,NF,JPE
• 製品種目: EMPROVE^® ESSENTIAL
• 形状: fine powder; powder
• 粒径: ≤12 μm (d90)
• pH: 6-8 (20 °C, 100 g/L in H₂O)
• mp: 130 °C (decomposition)
• 密度: 1.62 g/cm³ at 20 °C
• アプリケーション: liquid formulation; pharmaceutical; solid formulation
• 保管温度: 15-25°C
• SMILES記法: OC[C@H]1O[C@H](O[C@]2(CCl)O[C@H](CCl)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1Cl
• InChI: 1S/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2/t4-,5-,6+,7-,8+,9-,10+,11-,12+/m1/s1
• InChI Key: BAQAVOSOZGMPRM-QBMZZYIRSA-N

詳細

詳細

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

アプリケーション

Sucralose is a high-intensity sweetener which is non-cariogenic and suitable for diabetics and patients with an impaired glucose tolerance. In addition, it is readily soluble and masks both bitterness and medicinal off-notes with equal ease – making it exceptionally well-suited for pharmaceutical applications.
Our Sucralose is available in micronized or granular form, both pharmaceutical grade, allowing you to choose depending on your individual needs. Due to its optimal dispersion behavior, sucralose powder is typically recommended for solid dose formulations, while the fast dissolution behavior of sucralose granular makes it very well-suited for liquid formulations.

生物化学的／生理学的作用

人工甘味料です。舌で味を感知することができます。腸内分泌細胞上で甘味受容体T1R2/T1R3を活性化させ、グルカゴン様ペプチド-1およびグルコース依存性インスリン分泌ペプチドの分泌を促します。

特徴および利点

• Excellent sugar-like taste profiles
• Masking bitter aftertaste and medical off-notes with ease
• High sweetness potency offers improved cost-efficiency
• Enhanced stability
• Non-cariogenic and suitable for diabetics and patients with phenylketonuria

法的情報

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

The substance 1.00894 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable