653233

2,4-ジクロロ-5-フルオロピリミジン

97%

• 実験式（ヒル表記法）: C₄HCl₂FN₂
• CAS番号: 2927-71-1
• 分子量: 166.97
• MDL番号: MFCD00233551
• UNSPSCコード: 12352100
• PubChem Substance ID: 24883938
• NACRES: NA.22

特性

• 品質水準: 100
• アッセイ: 97%
• 形状: solid
• mp: 37-41 °C (lit.)
• 官能基: chloro; fluoro
• SMILES記法: Fc1cnc(Cl)nc1Cl
• InChI: 1S/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H
• InChI Key: WHPFEQUEHBULBW-UHFFFAOYSA-N

詳細

アプリケーション

2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize:

• 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors.
• A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors.
• 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors.
• 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA.
• 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst.
• 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.

安全性情報

• ピクトグラム: GHS05,GHS07
• シグナルワード: Danger
• 危険有害性情報: H302,H314,H317
• 注意書き: P260 - P272 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1A
• 保管分類コード: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• 引火点(°F): 222.8 °F - closed cup
• 引火点(℃): 106 °C - closed cup
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges