511617

6-クロロプリン

99%

• 実験式（ヒル表記法）: C₅H₃ClN₄
• CAS番号: 87-42-3
• 分子量: 154.56
• Beilstein: 5774
• EC Number: 201-745-6
• MDL番号: MFCD00075825
• UNSPSCコード: 12352100
• PubChem Substance ID: 24873552
• NACRES: NA.22

特性

• 品質水準: 100
• アッセイ: 99%
• mp: >300 °C (dec.) (lit.)
• 官能基: chloro
• SMILES記法: Clc1ncnc2[nH]cnc12
• InChI: 1S/C5H3ClN4/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H,7,8,9,10)
• InChI Key: ZKBQDFAWXLTYKS-UHFFFAOYSA-N

詳細

詳細

6-Chloropurine (6-CIPH), a 6-substituted purine derivative, is an antileukemic drug. It can be prepared by the chlorination of hypoxanthine with phosphorus oxychloride in the presence of dimethylaniline. The NMR-based conformational analysis of the products formed during the reaction of 6-CIPH with 3,4-di-O-acetyl-D-xylal and 3,4-di-O-acetyl-L-arabinal have been reported. 6-CIPH can undergo palladium-catalyzed cross coupling with organostannanes at 6-position to form the corresponding arylated or alkylated products.

アプリケーション

6-Chloropurine may be used:

• To prepare purine via catalytic dehydrogenation.
• To prepare 9-alkylated adenines via Mitsunobu reaction with various alcohols.
• As a starting material to synthesize dihydroisoxazole 6-chloropurine.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves