103276

ハルマン

98%

• 別名: 1-メチル-9H-ピリド[3,4-b]インドール, 2-メチル-β-カルボリン, アリビン
• 実験式（ヒル表記法）: C₁₂H₁₀N₂
• CAS番号: 486-84-0
• 分子量: 182.22
• Beilstein: 143898
• EC Number: 207-642-2
• MDL番号: MFCD00004957
• UNSPSCコード: 12352100
• PubChem Substance ID: 24846602
• NACRES: NA.22

特性

• 品質水準: 100
• アッセイ: 98%
• drug control: stupéfiant (France)
• mp: 235-238 °C (lit.)
• 溶解性: methanol: soluble 50mg/ml
• SMILES記法: Cc1nccc2c3ccccc3[nH]c12
• InChI: 1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3
• InChI Key: PSFDQSOCUJVVGF-UHFFFAOYSA-N
• 遺伝子情報: human ... CYP2D6(1565) ; rat ... Gabra2(29706)

詳細

詳細

• Harmane is a potent tremor-producing β-carboline alkaloid and neurotoxin.
• It is major representative of heterocyclic aromatic amines, a group of mutagenic and carcinogenic substances which are formed in meat from the precursors creatine, creatinine, amino acids and sugars during the heating at high temperatures.
• Blood harmane concentration is elevated in essential tremor, late-life neurological disease.

アプリケーション

• Harmane was used in trace level determination of harmane by planar chromatography coupled with (tandem) mass spectrometry.
• It was used to study interactions of norharman and harman with DNA.
• It may be used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix.

生物化学的／生理学的作用

I₁ イミダゾリン結合部位アゴニスト。

調製ノート

Harmane dissolves in methanol at a concentration of 50mg/ml to form a clear, colourless to yellow solution.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H315
• 注意書き: P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364
• 危険有害性の分類: Acute Tox. 4 Oral - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)