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O0886

Sigma-Aldrich

Olomoucine

≥98% (HPLC)

Sinonimo/i:

2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine

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About This Item

Formula empirica (notazione di Hill):
C15H18N6O
Numero CAS:
101622-51-9
Peso molecolare:
298.34
Numero MDL:
MFCD00189360
Codice UNSPSC:
12352200
ID PubChem:
24278053
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Solubilità

DMSO: 20 mg/mL, clear, colorless

Temperatura di conservazione

−20°C

Stringa SMILE

Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12

InChI

1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)
GTVPOLSIJWJJNY-UHFFFAOYSA-N

Informazioni sul gene

human ... CDC2(983) , CDK2(1017) , CDK3(1018) , CDK4(1019) , CDK5(1020) , CDK6(1021) , CDK7(1022) , CDK8(1024) , CDK9(1025) , CDKN1A(1026) , CDKN1B(1027) , CDKN1C(1028) , CDKN2A(1029) , CDKN2B(1030) , CDKN2C(1031) , CDKN2D(1032) , CDKN3(1033)
rat ... Prkca(24680)

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Azioni biochim/fisiol

Olomoucine is a purine derivative which inhibits cyclin-dependent kinases and induces G arrest.

Caratteristiche e vantaggi

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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R T Abraham et al.
Biology of the cell, 83(2-3), 105-120 (1995-01-01)
Olomoucine (2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine) has been recently described as a competitive inhibitor (ATP-binding site) of the cell cycle regulating p34cdc2/cyclin B, p33cdk2/cyclin A and p33cdk2/cyclin E kinases, the brain p33cdk5/p35 kinase and the ERK1/MAP-kinase. The unusual specificity of this compound towards cell
Brajendra K Tripathi et al.
Molecular vision, 14, 542-549 (2008-04-04)
To investigate the effect of the Cdk5 inhibitor olomoucine on corneal debridement wound healing in vivo. Corneal debridement wounds of 1.5 mm were made on the ocular surface of CD-1 mice. A 20 microl drop of 15 microM olomoucine in
Wei Mao et al.
Journal of experimental & clinical cancer research : CR, 31, 49-49 (2012-05-25)
Gastrokine-1 (GKN1), a secreted protein, is specifically expressed in gastric mucosa to protect and maintain the integrity of gastric epithelium. The present study investigated differential expression of GKN1 in normal, precancerous, and cancerous gastric tissues, and explored the biological functions
J Veselý et al.
European journal of biochemistry, 224(2), 771-786 (1994-09-01)
While testing purines related to the non-specific protein kinase inhibitors N6-dimethylaminopurine and N6-(delta 2-isopentenyl)adenine as potential inhibitors of the p34cdc2/cyclin B kinase, we discovered a compound with high specificity, 2-(2-hydroxyethylamino)-6- benzylamino-9-methylpurine (olomoucine). Kinetic analysis of kinase inhibition reveals that olomoucine
Takuro Tojima et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(21), 7165-7178 (2014-05-23)
Extracellular molecular cues guide migrating growth cones along specific routes during development of axon tracts. Such processes rely on asymmetric elevation of cytosolic Ca(2+) concentrations across the growth cone that mediates its attractive or repulsive turning toward or away from

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