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CDKN1C

cyclin-dependent kinase inhibitor 1C (p57, Kip2)

Synonyms:
BWCR, BWS, KIP2, WBS, p57, p57Kip2
Species:
Human CDKN1C (1028), Mouse Cdkn1c (12577), Rat Cdkn1c (246060), Zebrafish cdkn1c (399483), cow CDKN1C (510972), sheep CDKN1C (100216434), naked mole-rat Cdkn1c (101726530)
UniProtKB ID:
P49918
Gene ID:
  • Human(1028) Summary: This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
  • Mouse(12577) cyclin-dependent kinase inhibitor 1C (P57)
  • Rat(246060) cyclin-dependent kinase inhibitor 1C
  • Zebrafish(399483) cyclin-dependent kinase inhibitor 1C
  • cow(510972) cyclin-dependent kinase inhibitor 1C (p57, Kip2)
  • sheep(100216434) cyclin-dependent kinase inhibitor 1C (p57, Kip2)
  • naked mole-rat(101726530) cyclin-dependent kinase inhibitor 1C (p57, Kip2)

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
ZRB2530
Anti-p57Kip2 Antibody, clone 1H11 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
06-556
Anti-Kip2 Antibody, Upstate®, from rabbit,
Species Reactivity
bovine, human
Application
immunoprecipitation (IP)
western blot
HPA002924
Anti-CDKN1C antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
SAB4500071
Anti-p57 KIP2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
western blot
457M-9
p57Kip2 (Kp10) Mouse Monoclonal Antibody, ,
Species Reactivity
human
Application
immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
R7772
Roscovitine, ≥98% (TLC),
Species
human, mouse, rat
O0886
Olomoucine, ≥98% (HPLC),
Species
human, rat

esiRNA

Product Number
Description
Species
EMU028861
MISSION® esiRNA, targeting mouse Cdkn1c,
Species
mouse