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Merck

CDKN1B

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Synonyms:
CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Species:
Human CDKN1B (1027), Mouse Cdkn1b (12576), Rat Cdkn1b (83571), chicken CDKN1B (374106), dog CDKN1B (403429), cow CDKN1B (512613), domestic cat CDKN1B (493958), chicken CDKN1B (769872), naked mole-rat Cdkn1b (101698721), domestic guinea pig Cdkn1b (100729359) ...More
UniProtKB ID:
P46527, Q16307, Q5U0H2, Q9BUS6
Gene ID:
  • Human(1027) Summary: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq, Jul 2008]
  • Mouse(12576) cyclin-dependent kinase inhibitor 1B
  • Rat(83571) cyclin-dependent kinase inhibitor 1B
  • chicken(374106) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • dog(403429) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • cow(512613) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • domestic cat(493958) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • chicken(769872) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • naked mole-rat(101698721) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • domestic guinea pig(100729359) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • sheep(100127219) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • Domestic Rabbit(100009037) cyclin-dependent kinase inhibitor 1B (p27, Kip1)

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4504495
Anti-phospho-p27 Kip1 (pSer10) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
427M-9
p27Kip1 (SX53G8) Mouse Monoclonal Antibody, ,
Species Reactivity
human
Application
immunohistochemistry
SAB1403659
Monoclonal Anti-CDKN1B, (C-terminal) antibody produced in mouse, clone 2F4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
HPA059086
Anti-CDKN1B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
06-445
Anti-Kip1 (p27) Antibody, Upstate®, from rabbit,
Species Reactivity
human, rabbit, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
R7772
Roscovitine, ≥98% (TLC),
Species
human, mouse, rat
O0886
Olomoucine, ≥98% (HPLC),
Species
human, rat

Proteins

Product Number
Description
Species
SRP5109
p27KIP1, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
23-024-M
p27 Protein complex, activated, 10 µg, Activated complex of three (3) full length, recombinant human proteins: p27, Cyclin E1, & CDK2. Phosphorylated in vitro using CDK2/Cyclin E1. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.,
Species
human

esiRNA

Product Number
Description
Species
EMU028461
MISSION® esiRNA, targeting mouse Cdkn1b,
Species
mouse
EHU025821
MISSION® esiRNA, targeting human CDKN1B,
Species
human