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H7665

Sigma-Aldrich

Anti-Histone H1.4 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-H1 Histone family, member 4, Anti-H1.4, Anti-H1F4, Anti-HIST1H1E, Anti-Histone H1b, Anti-Histone I family, 4, Anti-Histone cluster 1 H1e

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen ~35 kDa

Reattività contro le specie

human

Concentrazione

~1.0 mg/mL

tecniche

western blot: 1-2 μg/mL using acid-extracted fraction of HL60 cells

N° accesso UniProt

P10412

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... HIST1H1E(3008)

Descrizione generale

In mammalian cells, four histone H1 variants (H1.2 to H1.5) are found in all somatic cells, and a fifth (H1.1) is present in thymus, testis and spleen, lymphocytic and neuronal cells. K26/H1.4 is present within the flexible N-terminal domain of H1.4 just before the globular domain. Histone modifications are thought to play an important role in cancer and disease.

Applicazioni

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Azioni biochim/fisiol

Linker histone H1 binds to DNA between nucleosomal core particles and is involved in establishing and maintaining higher order chromatin structures. It is covalently modified. Histone H1 phosphorylation occurs at multiple sites including at Ser27 residue. Histone H1.4 is di-methylated or acetylated at Lys26. enhancer of Zeste 2 (Ezh2).

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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HP1 binds specifically to Lys26-methylated histone H1. 4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding
Daujat S, et al.
Test, 280(45), 38090-38095 (2005)
Lucy A McNamara et al.
Journal of virology, 86(17), 9337-9350 (2012-06-22)
The ability of HIV-1 to establish a latent infection presents a barrier to curing HIV. The best-studied reservoir of latent virus in vivo is resting memory CD4(+) T cells, but it has recently been shown that CD34(+) hematopoietic progenitor cells
Sarka Jelinkova et al.
International journal of molecular sciences, 22(9) (2021-06-03)
Duchenne muscular dystrophy (DMD) is a devastating condition shortening the lifespan of young men. DMD patients suffer from age-related dilated cardiomyopathy (DCM) that leads to heart failure. Several molecular mechanisms leading to cardiomyocyte death in DMD have been described. However
Sullivan Renouard et al.
BMC research notes, 5, 15-15 (2012-01-11)
While seed biology is well characterized and numerous studies have focused on this subject over the past years, the regulation of seed coat development and metabolism is for the most part still non-elucidated. It is well known that the seed
Jikui Xiong et al.
Oncology letters, 15(4), 4767-4774 (2018-03-20)
Malignant melanoma is characterized by rapid deterioration, early metastasis and high mortality. Cdk5 regulatory subunit-associated protein 1 (CDK5RAP1), which catalyzes 2-methylthio (ms2) modification of mitochondrial transfer RNAs, has been reported to induce cancer cell apoptosis, by a phospho-c-Jun N-terminal kinase
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