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C8982

Sigma-Aldrich

α-Cyano-4-hydroxycinnamic acid

suitable for MALDI-TOF MS

Sinonimo/i:

α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA

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About This Item

Formula condensata:
HOC6H4CH=C(CN)CO2H
Numero CAS:
28166-41-8
Peso molecolare:
189.17
Beilstein:
3271427
Numero CE:
248-879-1
Numero MDL:
MFCD00004204
Codice UNSPSC:
12352106
ID PubChem:
24893121
NACRES:
NA.21

Forma fisica

powder

Livello qualitativo

500

Classi chimiche degli analiti

glycans, peptides, proteins

Punto di fusione

245-250 °C (lit.)

Compatibilità

suitable for MALDI-TOF MS

Temperatura di conservazione

room temp

Stringa SMILE

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
AFVLVVWMAFSXCK-VMPITWQZSA-N

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Descrizione generale

α-Cyano-4-hydroxycinnamic acid (CHCA) is specially purified and qualified as a matrix for peptide MALDI-MS (matrix assisted laser desorption ionization-mass spectrometry) calibration standards. CHCA enhances ionization of protein or peptide standards and samples in matrix assisted laser desorption ionization (MALDI) mass spectrometers.
It is also available as part of our ProteoMass™ MALDI calibration kits (MS-CAL1 and MS-CAL3).

Applicazioni

α-Cyano-4-hydroxycinnamic acid has been used as a matrix for MALDI-TOF MS (matrix assisted laser desorption ionization-time of flight mass spectrometry) analysis. The matrix has also been used for sample preparation.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Note legali

6538 is a trademark of American Type Culture Collection
ProteoMass is a trademark of Sigma-Aldrich Co. LLC

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Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H317

Classi di pericolo

Skin Sens. 1B

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

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dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Utilizing isotope dilution-matrix-assisted laser desorption ionization-time of flight mass spectrometry as a reference procedure for the radioimmunoassay of serum thyroxine.
Tyan YC, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 420, 99-103 (2013)
a-Cyano-4-hydroxycinnamic acid as a matrix for matrixassisted laser desorption mass spectromtry.
Beavis RC, et al.
Journal of Mass Spectrometry : Jms, 27, 156-158 (1992)
MALDI-TOF MS sample preparation by using alkanethiolate self-assembled monolayers: A preliminary application for protein sample analysis.
Tyan Y-C, et al.
International Journal of Mass Spectrometry, 262, 67-72 (2007)
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), a-, and ?-melanocyte stimulating hormone (a-MSH, and ?-MSH), and the conserved core motif HFRW.
N?hr AC, et al.
Neurochemistry International, 102, 105-113 (2017)
J Gobom et al.
Analytical chemistry, 73(3), 434-438 (2001-02-24)
We present a new MALD1 sample preparation technique for peptide analysis using the matrix alpha-cyano-4-hydroxy-cinnamic acid (CHCA) and prestructured sample supports. The preparation integrates sample purification, based on the affinity of microcrystalline CHCA for peptides, thereby simplifying the analysis of
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